White matter structure in autism: Preliminary evidence from diffusion tensor imaging
White matter structure in autism: Preliminary evidence from diffusion tensor imaging
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DOI：
10.1016/j.biopsych.2003.10.022
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发表时间：
2004-02-01
影响因子：
10.6
通讯作者：
Reiss, AL
中科院分区：
文献类型：
--
作者：
Barnea-Goraly, N;Kwon, H;Reiss, AL
背景：自闭症患者在社会沟通和人际关系方面有严重的困难。先前的研究表明，对社会认知重要的大脑区域之间的异常连接可能导致自闭症中的社会缺陷。在这项研究中，我们使用扩散张量成像调查白色物质结构在7名男性儿童和青少年与自闭症和9个年龄，性别和智商匹配的对照subjects.Results：减少分数各向异性（FA）值观察到白色物质毗邻的腹内侧前额叶皮质和前扣带回以及在颞顶交界处。在邻近双侧上级颞沟、双侧接近杏仁核的颞叶、枕颞束和胼胝体中观察到FA值降低的其他集群。与社会功能有关的区域之间的白色物质束的破坏可能会导致自闭症患者的社会认知受损。
Background: Individuals with autism have severe difficulties in social communication and relationships. Prior studies have suggested that abnormal connections between brain regions important for social cognition may contribute to the social deficits seen in autism.Methods. In this study, we used diffusion tensor imaging to investigate white matter structure in seven male children and adolescents with autism and nine age-, gender-, and IQ-matched control subjects.Results: Reduced fractional anisotropy (FA) values were observed in white matter adjacent to the ventromedial prefrontal cortices and in the anterior cingulate gyri as well as in the temporoparietal junctions. Additional clusters of reduced FA values were seen adjacent to the superior temporal sulcus bilaterally, in the temporal lobes approaching the amygdala bilaterally, in occipitotemporal tracts, and in the corpus callosum.Conclusions. Disruption of white matter tracts between regions implicated in social functioning may contribute to impaired social cognition in autism.