NATURES CHEMICALS AND SYNTHETIC CHEMICALS - COMPARATIVE TOXICOLOGY .3.
NATURES CHEMICALS AND SYNTHETIC CHEMICALS - COMPARATIVE TOXICOLOGY .3.
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DOI：
10.1073/pnas.87.19.7782
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发表时间：
1990-10-01
影响因子：
11.1
通讯作者：
GOLD, LS
中科院分区：
文献类型：
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作者：
AMES, BN;PROFET, M;GOLD, LS
合成化学品的毒理学与天然化学品的毒理学进行了比较，天然化学品代表了人类接触到的大部分化学品。有人认为，动物有一系列广泛的可诱导的一般防御措施来对抗植物性食物中不断变化的有毒化学物质（自然界的杀虫剂），这些防御措施对天然和合成毒素都有效。二恶英等合成毒素与天然化学物质，如吲哚甲醇（西兰花中）和乙醇进行了比较。讨论了合成农药和天然农药之间的权衡。在高剂量试验中，高比例的天然和合成化学品都是致癌物、诱变剂、致畸剂和致幻剂（每组占30-50%），这一发现破坏了目前保护公众健康免受基于这些试验的合成化学品危害的监管努力。
The toxicology of synthetic chemicals is compared to that of natural chemicals, which represent the vast bulk of the chemicals to which humans are exposed. It is argued that animals have a broad array of inducible general defenses to combat the changing array of toxic chemicals in plant food (nature''s pesticides) and that these defense are effective against both natural and synthetic toxins. Synthetic toxins such as dioxin are compared to natural chemicals, such as indole carbinol (in broccoli) and ethanol. Trade-offs between synthetic and natural pesticides are discussed. The finding that in high-dose tests, a high proportion of both natural and synthetic chemicals are carcinogens, mutagens, teratogens, and clastogens (30-50% for each group) undermines current regulatory efforts to protect public health from synthetic chemicals based on these tests.