The origin of thalamic inputs to the arcuate premotor and supplementary motor areas
The origin of thalamic inputs to the arcuate premotor and supplementary motor areas
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DOI：
10.1523/jneurosci.04-02-00539.1984
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发表时间：
1984-02
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影响因子：
--
通讯作者：
G. Schell;P. Strick
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文献类型：
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作者：
G. Schell;P. Strick
我们已经使用了小麦胚芽凝集素结合辣根过氧化物酶逆行运输检查丘脑输入到两个运动前区的起源与dendritic预测的运动皮层：弓状运动前区（阿帕）和辅助运动区（SMA）。逆行运输表明，这两个运动前区和运动皮层每个接收丘脑输入从单独的，cytoarchitectonically定义良好的腹外侧丘脑的分区。根据Olszewski的命名法（Olszewski，J.（1952）The Thalamus of the Macaca mulatta.立体定位仪用图谱。Karger，AG，巴塞尔），对阿帕的输入主要来源于X区，对SMA的输入主要来源于腹外侧核的口部亚区（VLo），对运动皮层的输入主要来源于腹后外侧核的口部亚区（VPLo）。这些观察结果，结合先前关于丘脑中各种皮质下传出神经终止的研究，导致以下连接方案：（1）小脑深核的吻侧部分通过VPLo投射到运动皮质;（2）小脑深核的尾侧部分通过X区投射到阿帕;（3）苍白球通过VLo投射到SMA。因此，每个丘脑皮层通路都与不同的皮层下输入有关。
We have used retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase to examine the origin of thalamic input to the two premotor areas with the densest projections to the motor cortex: the arcuate premotor area (APA) and the supplementary motor area (SMA). Retrograde transport demonstrated that the two premotor areas and the motor cortex each receive thalamic input from separate, cytoarchitectonically well defined subdivisions of the ventrolateral thalamus. According to the nomenclature of Olszewski (Olszewski, J. (1952) The Thalamus of the Macaca mulatta. An Atlas for Use with the Stereotaxic Instrument, S. Karger, AG, Basel), input to the APA originates largely from area X, input to the SMA originates largely from the pars oralis subdivision of nucleus ventralis lateralis (VLo), and that to the motor cortex originates largely from the pars oralis subdivision of nucleus ventralis posterior lateralis (VPLo). These observations, when combined with prior studies on the termination of various subcortical efferents in the thalamus, lead to the following scheme of connections: (1) rostral portions of the deep cerebellar nuclei project to the motor cortex via VPLo; (2) caudal portions of the deep cerebellar nuclei project to the APA via area X; and (3) the globus pallidus projects to the SMA via VLo. Thus, each thalamocortical pathway is associated with a distinct subcortical input.