Tissue microenvironment and the genetic control of hair pigment patterns in mice
Tissue microenvironment and the genetic control of hair pigment patterns in mice
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组织微环境与小鼠毛发色素模式的遗传控制
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
Nancy L. Brewer
中科院分区：
文献类型：
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作者：
D. B. Galbraith;G. Wolff;Nancy L. Brewer
本研究旨在评估遗传相同小鼠的皮肤组织内的微环境变异性，这些微环境变异性与特定的细胞反应有关：毛球黑色素细胞周期性合成黄色和黑色色素。在小鼠的近交系内和近交系之间进行杂交，所述近交系是除在agglutamine基因座处的单个基因取代之外的同基因的。Agglutinase基因座基因包括Avy、Aw、A、atd、at、ax、am和a等位基因。研究了第一和第三代毛的背侧、侧腹和腹侧毛的色素模式，以及在特殊皮肤区域（如耳廓、尾巴和后足）生长的毛的色素模式。研究发现，在遗传上相同的小鼠中，毛球黑色素细胞合成的黄色色素的量既与年龄有关，又受皮肤环境的制约。此外，特殊的外皮区域产生的毛发具有多种色素模式，其中黑色和黄色色素的分布和相对量不一定符合agarpus基因座等位基因之间预期的显性关系，这是根据它们对背侧皮毛色素沉着的影响来判断的。我们的结论是，在遗传均匀的表皮组织，微环境的差异发生，并反映在分化细胞的代谢模式的改变。
This study was conducted to assess microenvironmental variability within integumental tissue of genetically identical mice with respect to a specific cellular response: cyclic synthesis of yellow and black pigment by hair bulb melanocytes. Crosses were performed within and between inbred strains of mice that were isogenic with the exception of a single gene substitution at the agouti locus. Agouti locus genes included the Avy, Aw, A, atd, at, ax, am, and a alleles. The pigment patterns of dorsal, flank, and ventral hairs of the first and third hair generations and of hairs growing in special integumentary areas such as the pinna, tail, and hind foot were studied. It was found that the amount of yellow pigment synthesized by hair bulb melanocytes within genetically identical mice is both agedependent and conditioned by the integumentary environment. Furthermore, the special integumentary regions produce hairs with a variety of pigment patterns in which the distribution and relative amounts of black and yellow pigments do not necessarily conform to dominance relationships expected among agouti locus alleles as judged by their effects on the pigmentation of the dorsal pelage. We conclude that within genetically uniform integumental tissues, microenvironmental differences occur and are reflected as alterations in the metabolic pattern of differentiated cells.