Neuroendocrine cells of the prostate and neuroendocrine differentiation in prostatic carcinoma: A review of morphologic aspects
Neuroendocrine cells of the prostate and neuroendocrine differentiation in prostatic carcinoma: A review of morphologic aspects
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DOI：
10.1016/s0090-4295(98)00064-8
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发表时间：
1998-05-01
期刊：
影响因子：
2.1
通讯作者：
Di Sant'Agnese, PA
中科院分区：
文献类型：
--
作者：
Di Sant'Agnese, PA
前列腺神经内分泌细胞是上皮内调节细胞，分泌血清素和多种肽激素。据推测，这些细胞通过内分泌、旁分泌、神经分泌和管分泌机制调节生长和分化以及外分泌活性。前列腺癌的神经内分泌分化表现为纯粹的神经内分泌恶性肿瘤，如小细胞癌和类癌/类癌样肿瘤，而更常规的前列腺腺癌则表现为局灶性神经内分泌分化。前列腺癌的神经内分泌分化可能具有诊断和预后意义。(C) 1998, Elsevier Science Inc.；版权所有。
Neuroendocrine cells of the prostate are intraepithelial regulatory cells that secrete serotonin and a variety of peptide hormones. it is hypothesized that these cells regulate both growth and differentiation, as well as exocrine secretory activity through endocrine, paracrine, neurocrine, and lumenocrine mechanisms. Neuroendocrine differentiation in prostatic carcinoma occurs as pure neuroendocrine malignancies, such as small-cell carcinoma and carcinoid/carcinoid-like tumors, as well as focal neuroendocrine differentiation in a more conventional prostatic adenocarcinoma. Neuroendocrine differentiation in prostatic carcinoma may have diagnostic and prognostic significance. (C) 1998, Elsevier Science Inc. All rights reserved.