Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation
Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation
复制标题
聚（Boc-丙烯酰肼）：温度和 RAFT 剂降解对其制备的重要性
DOI：
10.1039/c9py01222b
复制
发表时间：
2019
影响因子：
4.6
通讯作者：
Creese O
中科院分区：
文献类型：
--
作者：
Creese O
聚(丙烯酰肼)是一种多功能的聚合物支架，可以通过与醛的聚合后修饰来实现功能化，从而生成用于生物应用的聚合物。然而，它的聚合受到RAFT试剂亲核降解的影响，从而导致提前终止，这是初级丙烯酰胺聚合中经常被忽视的一个问题。本文报道了温度对N‘-(叔丁氧甲酰基)丙烯酰肼(1)RAFT聚合的影响，并证明了通过仔细选择聚合温度，可以在聚合速率和RAFT试剂的降解速率之间取得平衡。通过这种方式，可以更好地控制聚合过程，使合成的BOC保护的聚丙烯酰肼的聚合度(DP)高于以前获得的聚合度(DP)，同时仍保持低分散性(ĐM)。
Poly(acryloyl hydrazide) is a versatile polymer scaffold readily functionalised through post-polymerisation modification with aldehydes to yield polymers for biological applications. However, its polymerisation is affected by nucleophilic degradation of the RAFT agent that leads to early termination, an issue often overlooked in the polymerisation of primary acrylamides. Here we report the effect of temperature on the RAFT polymerisation of N′-(tert-butoxycarbonyl)acryloyl hydrazide (1) and demonstrate that by carefully selecting this polymerisation temperature, a balance between rate of polymerisation and rate of degradation of the RAFT agent can be achieved. This way greater control over the polymerisation process is achieved, allowing the synthesis of Boc-protected poly(acryloyl hydrazide) with higher degrees of polymerisation (DP) than those obtained previously, while still maintaining low dispersities (ĐM).