Randomized trial of bone marrow versus lenograstim-primed blood cell allogeneic transplantation in patients with early-stage leukemia: A report from the Societe Francaise de Greffe de Moelle
Randomized trial of bone marrow versus lenograstim-primed blood cell allogeneic transplantation in patients with early-stage leukemia: A report from the Societe Francaise de Greffe de Moelle
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DOI：
10.1200/jco.2000.18.3.537
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发表时间：
2000-02-01
影响因子：
45.3
通讯作者：
Michalle, M
中科院分区：
文献类型：
--
作者：
Blaise, D;Kuentz, M;Michalle, M
目的：比较异基因血细胞移植（BCT）和异基因骨髓移植（BMT.Patients and Methods）患者的血液学恢复情况。101例接受移植，采用标准程序收集和移植。患者在接受移植后未接受预防性粒细胞集落刺激因子。除了临床终点正在建立，移植后的前6个月的前瞻性和比较经济evaluations.Results：各组患者，供体和移植的特点是平衡的。血细胞采集导致采集的CD 34（+）和CD 3（+）细胞数量高于骨髓采集（p < 10（-6）），且未报告对供体的副作用。BCT组患者的血小板计数达到25和50 × 10（9）血小板/L 8天，分别比BMT组早（P < 10（-4）和P < 10（-5））。这导致前一组在移植后的前180天内血小板输注较少（P = .002）。BCT组中性粒细胞计数达到0.5和1 × 109/L的时间分别比BMT组短6天和7天（P < 10 - 5）。这种更快的血液学恢复与较短的住院时间和减少总成本的程序在前6 months.Conclusion：这项研究建立了同种异体骨移植的结果在更快的血液学恢复，但与慢性移植物抗宿主病的发生率较高。J Clin Oncol 18：537-546. (C)2000年，美国临床肿瘤学会。
Purpose: To compare hematologic recovery in patients receiving allogeneic blood cell transplantation (BCT) with those receiving allogeneic bone marrow transplantation (BMT).Patients and Methods: One hundred eleven patients with leukemia in the early stages and with HLA-matched sibling donors were randomized in this study. One hundred one underwent transplantation, Standard procedures for collection and transplantation were used. Patients did not receive prophylactic granulocyte colony-stimulating factor after undergoing transplantation. In addition to clinical end points being established, a prospective and comparative economic evaluation of the first 6 months after transplantation was performed.Results: Groups were balanced for patient, donor, and transplant characteristics. Blood cell collection led to the collection of a higher number of CD34(+) and CD3(+) cells than did bone marrow collection (p < 10(-6)) without reported side effects for the donor. Patients in the BCT group reached platelet counts of 25 and 50 x 10(9) platelets/L 8 and it days earlier than did the BMT group (P < 10(-4) and P < 10(-5)), respectively. This resulted in fewer platelet transfusions during the first 180 days after transplantation (P = .002) for the former group. The time to reach neutrophil counts of 0.5 and 1 x 10(9) neutrophils/L was 6 and 7 days shorter, respectively, in the BCT group than in the BMT group (P < 10(-5)). This quicker hematologic recovery was associated with a shorter length of hospitalization and a decrease in total cost of procedure during the first 6 months.Conclusion: This study establishes that allogeneic BCT results in quicker hematologic recovery but is associated with a higher occurrence of chronic graft-versus-host disease. J Clin Oncol 18:537-546. (C) 2000 by American Society of Clinical Oncology.