Dry powder coated osmotic drug delivery system
Dry powder coated osmotic drug delivery system
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DOI：
10.1016/j.ejps.2017.10.001
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发表时间：
2018-01
影响因子：
4.6
通讯作者：
Qingliang Yang;Yingliang Ma;Jesse Zhu
中科院分区：
文献类型：
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作者：
Qingliang Yang;Yingliang Ma;Jesse Zhu
采用粉末包衣技术制备了干粉包衣渗透给药系统(ODDS)，并对其进行了表征。首先通过静电喷枪将涂层粉末粘结到ODDS芯的表面，然后进行固化步骤，使这些电沉积的颗粒聚集并形成连续、均匀和坚固的涂层，这是ODDS的半透膜。柠檬酸三乙酯(TEC)是一种比PEG400更好的液体增塑剂，无论是在降低涂层聚合物(醋酸纤维素)的玻璃化转变温度方面，还是在提高ODDS芯的导电性方面都是一种更好的液体增塑剂，这两者都能提高涂层粉末的附着力和成膜性。扫描电子显微镜结果表明，随着固化时间和温度的不同，涂层的均匀性有很大的不同。以硫酸沙丁胺醇和布洛芬为模型药物。两者的释药曲线均为零级释药动力学。两种药物从粉末包衣中的释药速率可以通过改变包衣程度来调节，但与搅拌速度和释放介质的pH无关。
Dry powder coated osmotic drug delivery system (ODDS) were prepared and characterized using an innovative powder coating technology. Coating powder adhesion to the surface of the ODDS core was firstly performed through an electrostatic spray gun, followed by a curing step to allow those electrically deposited particles coalesce and form a continuous, uniform and strong coating film, which is the semipermeable membrane of the ODDS. Triethyl citrate (TEC) was found to be a better liquid plasticizer than PEG 400 both in reducing the glass transition temperature of the coating polymer (cellulose acetate) and in increasing the electrical conductivity of the ODDS cores, both of which led to an enhanced coating powder adhesion and film formation. Results of SEM indicated that the uniformity of the coating film varied significantly with the difference of curing time and temperature. Salbutamol sulfate and ibuprofen were used as the model drugs. Release profiles of both showed that zero-order drug release kinetics was achieved. Release rate of both drugs from powder coated ODDS could be adjusted by changing the coating level but was independent of the agitation speed and of the pH of the release media.