Neurotoxic mechanisms of fish-borne methylmercury
Neurotoxic mechanisms of fish-borne methylmercury
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DOI：
10.1016/s1382-6689(02)00028-5
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发表时间：
2002-09-01
影响因子：
4.3
通讯作者：
Aschner, M
中科院分区：
文献类型：
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作者：
Aschner, M
甲基汞(MeHg)的流行和对食鱼人群的研究为甲基汞暴露的神经毒性后遗症提供了宝贵的见解。甲基汞是一种普遍存在的环境污染物，在人为和自然污染的情况下，其在食物链中的积累将继续构成健康风险。这篇综述简要介绍了与食鱼人群暴露于甲基汞有关的最新流行病学数据。确定甲基汞进入中枢神经系统(CNS)的机制，并讨论了关于甲基汞影响的细胞过程的各种理论，其中最肯定的包括星形细胞无法维持细胞外液的成分。(C)2002 Elsevier Science B.V.保留所有权利。
Methylmercury (MeHg) epidemics and studies in fish-eating populations have provided invaluable insights into the neurotoxic sequelae of MeHg exposure. MeHg is a ubiquitous environmental contaminant, and its accumulation in the rood chain will continue to pose health risks given anthropogenic and natural contamination. This review briefly addresses recent epidemiological data associated with exposure to MeHg in fish-eating populations. identifies mechanisms of MeHg transport into the central nervous system (CNS), and discusses various theories on cellular processes afflicted by MeHg, which most certainly include astrocytic failure to maintain the composition of the extracellular fluid. (C) 2002 Elsevier Science B.V. All rights reserved.