The discovery of IgE
The discovery of IgE
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DOI：
10.1016/j.jaci.2016.04.004
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发表时间：
2016-06-01
影响因子：
14.2
通讯作者：
Johansson, S. G. O.
中科院分区：
文献类型：
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作者：
Johansson, S. G. O.
1919 年，人们开始在过敏受试者的血清中寻找可能介导过敏（例如过敏性哮喘）的因子（后来称为反应素）。 1967年，第五类免疫球蛋白IgE被发现，并发现能够携带反应素活性。这一发现对于过敏性疾病的理解、诊断和治疗具有极其重要的意义。
In 1919, the search began for the factor, later called reagin, that could mediate an allergy, such as allergic asthma, in sera of allergic subjects. In 1967, the fifth class of immunoglobulins, IgE, was discovered and found to be able to carry reagin activity. This discovery has had immense importance for the understanding, diagnosis, and treatment of allergic diseases.