THE MURINE PAIRED BOX GENE, PAX7, IS EXPRESSED SPECIFICALLY DURING THE DEVELOPMENT OF THE NERVOUS AND MUSCULAR SYSTEM
THE MURINE PAIRED BOX GENE, PAX7, IS EXPRESSED SPECIFICALLY DURING THE DEVELOPMENT OF THE NERVOUS AND MUSCULAR SYSTEM
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DOI：
10.1016/0925-4773(90)90132-6
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发表时间：
1990-12-01
影响因子：
2.6
通讯作者：
GRUSS, P
中科院分区：
文献类型：
--
作者：
JOSTES, B;WALTHER, C;GRUSS, P
目前已分离到8个小鼠配对盒状基因（Pax）。这里描述的基因pax7不仅包含一个配对盒，还包含一个八肽和一个配对型同源盒。Northern和原位分析表明，Pax7在胚胎发生的第8天至第17天表达。在早期阶段，Pax7转录本存在于整个大脑的一部分细胞中，但在发育后期，表达仅限于中脑。在发育中的神经管中，Pax7局限于沿整个前后轴的脑室背区，提示Pax7在中枢神经系统某些部分的形成中起作用。此外，Pax7的表达可以在肌形成过程中被跟踪，从体的真皮组织到骨骼肌组织。
Eight murine paired box-containing (Pax) genes have been isolated so far. The gene described here, Pax 7, contains not only a paired box, but also an octapeptide and a paired-type homeobox. As shown by Northern and in situ analysis, Pax7 is expressed from day 8 to 17 p.c. during embryogenesis. At early stages Pax7 transcripts are present in a subset of cells throughout the entire brain, but later in development expression is limited to the mesencephalon. In the developing neural tube Pax7 is restricted to the dorsal ventricular zone along the entire antero-posterior axis, suggesting a role for Pax7 in the formation of certain parts of the CNS. Additionally Pax7 expression can be followed during myogenesis from the dermamyotome of the somites to the skeletal muscle tissues.