GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets
GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets
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GG167（4-guanidino-2,4-dideoxy-2,3-deHydro-N-乙酰神经氨酸）是雪貂流感病毒的有效抑制剂
DOI：
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发表时间：
1995
影响因子：
4.9
通讯作者：
M. Dempsey
中科院分区：
文献类型：
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作者：
D. M. Ryan;Julia Ticehurst;M. Dempsey
GG167(4-guanidino-2，4-dideoxy-2，3-dehydro-N-acetylneuraminic酸)是一种新型病毒神经氨酸酶(唾液酸酶)抑制剂，在雪貂鼻腔给药后，对甲型和乙型流感病毒的疗效至少是利巴韦林和金刚烷胺的100至1,000倍。即使将治疗推迟到感染后24小时，它仍保持其活性，并且对感染后的血清抗体反应没有影响。
GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a novel viral neuraminidase (sialidase) inhibitor which, following intranasal administration in ferrets, is at least 100 to 1,000 times more effective than ribavirin and amantadine against influenza A and B viruses. It retains its activity even when treatments are delayed until 24 h postinfection and has no effect on the serum antibody response to infection.