Diadenosine polyphosphate receptors from rat and guinea-pig brain to human nervous system
Diadenosine polyphosphate receptors from rat and guinea-pig brain to human nervous system
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DOI：
10.1016/s0163-7258(00)00049-8
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发表时间：
2000-08-01
影响因子：
13.5
通讯作者：
Miras-Portugal, MT
中科院分区：
文献类型：
--
作者：
Pintor, J;Díaz-Hernández, M;Miras-Portugal, MT
二腺苷多磷酸是一个家族的天然存在的核苷酸化合物存在于分泌囊泡与其他化学信使。这些化合物的胞吐释放允许它们刺激称为“嘌呤受体”或“ATP受体”的受体。“与对核苷敏感的嘌呤受体（P1）相比，核苷酸的嘌呤受体被命名为P2。P2受体进一步细分为代谢型P2Y受体（进一步分为5种亚型）和离子型P2X受体（具有7种不同亚型）。多磷酸二腺苷可以激活重组P2Y（1）、P2Y（2）和P2Y（4）以及重组同源P2X（1）、P2X（2）、P2X（3）、P2X（4）和P2X（6）。当不同亚基之间发生共组装时，异聚P2X受体改变其对多磷酸二腺苷的敏感性。二腺苷多磷酸可以激活称为二核苷酸受体或P4受体的特异性受体，其对其他核苷或核苷酸不敏感。P4受体是存在于大鼠脑突触终末的受体操纵的Ca 2+通道，由五磷酸二腺苷和四磷酸二腺苷刺激。该受体受蛋白激酶A和C以及蛋白磷酸酶的强烈调节。二核苷酸受体存在于不同的脑区域，如中脑（大鼠和豚鼠）、小脑（豚鼠）和皮质（人类）。(C)2000 Elsevier Science Inc. All rights reserved.
Diadenosine polyphosphates are a family of naturally occurring nucleotidic compounds present in secretory vesicles together with other chemical messengers. The exocytotic release of these compounds permits them to stimulate receptors termed "purinoceptors" or "ATP receptors." Purinoceptors for nucleotides are named P2 in contrast with those sensitive to nucleosides (P1). P2 receptors are fur ther subdivided into metabotropic P2Y receptors, further divided into 5 subtypes, and ionotropic P2X receptors, with 7 different subtypes. Diadenosine polyphosphates can activate recombinant P2Y(1), P2Y(2), and P2Y(4) and recombinant homomeric P2X(1), P2X(2), P2X(3), P2X(4), and P2X(6), Heteromeric P2X receptors change their sensitivity to diadenosine polyphosphates when co-assembly between different subunits occurs. Diadenosine polyphosphates can activate specific receptors termed dinucleotide receptors or P4 receptors, which are insensitive to other nucleosides or nucleotides. The P4 receptor is a receptor-operated Ca2+ channel present in rat brain synaptic terminals, stimulated by diadenosine pentaphosphate and diadenosine tetraphosphate. This receptor is strongly modulated by protein kinases A and C and protein phosphatases. The dinucleotide receptor is present in different brain areas, such as midbrain (in rat and guinea-pig), cerebellum (in guinea-pig), and cortex (in human). (C) 2000 Elsevier Science Inc. All rights reserved.