Somatic genital reflexes in rats with a nod to humans: anatomy, physiology, and the role of the social neuropeptides.
Somatic genital reflexes in rats with a nod to humans: anatomy, physiology, and the role of the social neuropeptides.
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DOI：
10.1016/j.yhbeh.2011.02.006
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发表时间：
2011-05
影响因子：
3.5
通讯作者：
Murphy, Anne Z.
中科院分区：
文献类型：
--
作者：
Normandin, Joseph J.;Murphy, Anne Z.
关键词：
身体生殖反射，如射精和阴道子宫收缩是通过与生殖器相关的横纹肌产生的。这些反射的协调是令人惊讶的复杂，涉及到腰骶椎和棘上系统的数量。大鼠模型已被证明是关于这些机制的极好信息来源，并且可以得出许多与人类研究相似的地方。通过几十年的研究，已经对涉及腰骶脊髓的脊髓系统（传出和传入）有了了解。脊髓和脊髓上的机制下行兴奋，通过脊髓射精发生器在腰椎和丘脑，下行抑制，通过腹外侧髓质，已被确定和特点解剖和生理。此外，描绘的神经回路，其中上行生殖器的信息调节的躯体生殖器反射是中继supraspinally也一直是最近的调查主题。最后，“社会神经肽”催产素和加压素在调节躯体生殖反射和相关的社会性行为中的重要性正在显现。这项工作不仅对理解神经系统如何产生性行为有意义，而且还为人们的性功能障碍提供了治疗目标。
Somatic genital reflexes such as ejaculation and vaginocervical contractions are produced through the striated muscles associated with the genitalia. The coordination of these reflexes is surprisingly complex and involves a number of lumbosacral spinal and supraspinal systems. The rat model has proved to be an excellent source of information regarding these mechanisms, and many parallels to research in humans can be drawn. An understanding of the spinal systems involving the lumbosacral spinal cord, both efferent and afferent, has been generated through decades of research. Spinal and supraspinal mechanisms of descending excitation, through a spinal ejaculation generator in the lumbar spinal cord and thalamus, and descending inhibition, through the ventrolateral medulla, have been identified and characterized both anatomically and physiologically. In addition, delineation of the neural circuits whereby ascending genitosensory information regarding the regulation of somatic genital reflexes is relayed supraspinally has also been the topic of recent investigation. Lastly, the importance of the “social neuropeptides” oxytocin and vasopressin in the regulation of somatic genital reflexes, and associated sociosexual behaviors, is emerging. This work not only has implications for understanding how nervous systems generate sexual behavior, but also provides treatment targets for sexual dysfunction in people.
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