Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review
Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review
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DOI：
10.1016/j.jep.2019.02.024
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发表时间：
2019-05-10
影响因子：
5.4
通讯作者：
Islam, Md Shahidul
中科院分区：
文献类型：
--
作者：
Chukwuma, Chika Ifeanyi;Matsabisa, Motlalepula G.;Islam, Md Shahidul
民族药理学相关性：糖尿病和高血压是与病理生理相关的疾病，与具有相似危险因素的更广泛复杂的代谢性疾病共存。世界各地的药用植物具有抗糖尿病和/或抗高血压作用，有大量的民族药理证据，这些药用植物被用作治疗糖尿病和高血压的药物。目的：本文综述了同一实验研究中报道的同时具有抗糖尿病和/或抗高血压作用的药用植物的研究结果，以促进抗糖尿病和高血压双效疗法的开发。材料和方法：通过文献检索不同的科学搜索引擎，包括但不限于PubMed，Google Scholar，“Scope us”和Science Direct，以确定已发表的数据，在这些数据中，同一实验研究中的植物被报告具有抗高血糖和抗高血压作用。结果：共有64项研究，102种植物符合筛选标准。豆科植物是被研究最多的植物，而不同植物的psi差异很大，只有11种植物的psi与之相似或相等。据报道，睡莲是唯一一种对人类具有降血糖和利尿作用的植物，可与道尼相媲美。咖啡酸、绿原酸、棕榈酸、菊花酸、马鞭草苷、亮子皂苷A、异Acteoside、岩藻黄质和烟酰胺是已知和/或从该植物中分离得到的具有降压和降压双重作用的化合物。结论：本研究表明，药用植物具有不同的抗高血压和抗糖尿病作用，可作为S或S治疗高血压和糖尿病的制剂或制剂。
Ethnopharmacological relevance: Diabetes and hypertension are pathophysiologically related diseases that coexist with a wider complex of metabolic diseases having similar set of risk factors. There are numerous ethnopharmacological evidences on the anti-diabetic and/or anti-hypertensive properties of medicinal plants from various parts of the world, which are used as therapies to concomitantly manage diabetes and hypertension.Aim of the review: This article reviewed findings on medicinal plants with both anti-diabetic and anti-hypertensive effects reported in same experimental study to facilitate the development of dual-acting therapies against diabetes and hypertension.Materials and methods: A literature search was carried out on different scientific search engines including, but not limited to "PubMed", "Google Scholar", "Scopus" and ScienceDirect to identify published data in which plants in same experimental studies were reported to possess both anti-hyperglycemic and anti-hypertensive effects. Subsequently, the anti-diabetic/anti-hypertensive potency ratio (psi) of the medicinal plants was computed.Results: Sixty-four studies with 102 plant species matched the selection criteria. Members of the Fabaceae family were the most investigated plants, while the psi greatly varied across the plants, with only 11 plants having a psi similar or equal to. Withania somnifera Dunal was the only plant reported to show blood glucose-lowering and diuretic effects in humans, comparable to daonil. Caffeic acid, chlorogenic acid, caftaric acid, cichoric acid, verbascoside, leucosceptoside A, isoacteoside, fucoxanthin and nicotinamide were the reported dual acting anti-diabetic and anti-hypertensive compounds identified and/or isolated in the plants.Conclusions: This review suggests that medicinal plants possess varied therapeutic dynamics against hypertension and diabetes that could be exploited for the discovery of therapeutic preparation(s) or agent(s) for treating the two diseases.