Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
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DOI：
10.1074/jbc.271.24.13939
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发表时间：
1996-06-14
影响因子：
4.8
通讯作者：
Kim, KH
中科院分区：
文献类型：
--
作者：
Bai, YL;Zhang, SY;Kim, KH
瘦素是oh基因的产物，控制着小鼠的食物摄入和体重减轻。虽然循环瘦素的目标被认为是大脑，然后协调食物摄入和体重减轻，但瘦素在减肥过程中如何起作用尚不清楚。在本报告中，我们提出证据，ob基因表达在培养细胞抑制乙酰辅酶a羧化酶基因表达和脂质合成的激素处理诱导。这是第一个发现瘦素在没有大脑参与的情况下抑制导致脂质积累的生化反应的例子。
Leptin, the product of the oh gene, controls food-intake and weight loss in the ob mouse. Although the target(s) of the circulating leptin is presumed to be the brain which then orchestrates food-intake and weight loss, how leptin functions in the process of weight loss is unknown. In this report, we present evidence that ob gene expression in cultured cells suppresses acetyl-CoA carboxylase gene expression and lipid synthesis which are induced by hormone treatment. This is the first example in which leptin has been found to suppress defined biochemical reactions that contribute to Lipid accumulation without the participation of the brain.