EFFECTS OF DESGLYCINAMIDE9, (ARG8)VASOPRESSIN AND VASOPRESSIN ANTISERUM ON THE ACQUISITION OF INTRAVENOUS COCAINE SELF-ADMINISTRATION IN THE RAT
EFFECTS OF DESGLYCINAMIDE9, (ARG8)VASOPRESSIN AND VASOPRESSIN ANTISERUM ON THE ACQUISITION OF INTRAVENOUS COCAINE SELF-ADMINISTRATION IN THE RAT
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DOI：
10.1016/0024-3205(88)90247-0
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发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
VANREE, JM
中科院分区：
文献类型：
--
作者：
DEVRY, J;DONSELAAR, I;VANREE, JM
研究了加压素神经肽去甘氨酸酰胺9（Arg 8）加压素（DGAVP）对静脉内可卡因自我给药获得的影响。在连续强化操作程序中，在每天5次3小时的会议期间，在体重减轻的条件下对大鼠进行测试。在这些条件下，用0.125和0.25（但不是0.063 mg.ml-1）可卡因获得的自我给药率超过了用生理盐水获得的速率。每日用DGAVP（5 μg/大鼠，s.c.）将0.125和0.25 mg.ml-1可卡因的自我给药降低到用盐水获得的水平，但对0.063 mg.ml-1可卡因和盐水的自我给药没有影响。使用类似的程序，研究表明，每日侧脑室内用加压素抗血清预处理显著增加了0.125 mg.ml-1可卡因的自我给药，而不影响0.063和0.25 mg.ml-1可卡因和生理盐水的自我给药。结果支持以前的研究结果与加压素神经肽在药物自我管理的研究，并表明，DGAVP减少收购可卡因自我管理通过减弱可卡因的增强作用，内源性加压素可能参与收购可卡因自我管理。
The effect of the vasopressin neuropeptide desglycinamide9, (Arg8) vasopressin (DGAVP) on the acquisition of intravenous cocaine self-administration was studied. Rats were tested under conditions of reduced body weight in a continuous reinforcement operant procedure, during five daily 3 h sessions. Under these conditions, the rate of self-administration obtained with 0.125 and 0.25, but not 0.063 mg.ml−1cocaine, exceeded the rate obtained with saline. Daily pretreatment with DGAVP (5 μg/rat, s.c.) decreased self-administration of 0.125 and 0.25 mg.ml−1cocaine to the level obtained with saline, but had no effect on self-administration of 0.063 mg.ml−1cocaine and saline. Using a similar procedure, it was shown that daily intracerebroventricular pretreatment with vasopressin antiserum significantly increased self-administration of 0.125 mg.ml−1cocaine, without affecting self-administration of 0.063 and 0.25 mg.ml−1cocaine and saline. The results support previous findings obtained with vasopressin neuropeptides in drug self-administration studies and suggest that DGAVP decreases the acquisition of cocaine self-administration by attenuating the reinforcing effects of cocaine and that endogenous vasopressin may be involved in the acquisition of cocaine self-administration.