Gastrointestinal mean transit times in young and middle-aged healthy subjects
Gastrointestinal mean transit times in young and middle-aged healthy subjects
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DOI：
10.1046/j.1365-2281.2001.00308.x
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发表时间：
2001-03-01
期刊：
影响因子：
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通讯作者：
Madsen, JL
中科院分区：
文献类型：
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作者：
Graff, J;Brinch, K;Madsen, JL
为了调查年龄和性别对胃、小肠和结肠平均通过时间的影响，对 32 名健康志愿者进行了一项研究：8 名年轻女性（22-30 岁）、8 名年轻男性（20-28 岁）、8 名中年女性（43-51 岁）和 8 名中年男性（38-53 岁）。摄入含有(111)铟标记的水和(99m)锝标记的煎蛋卷的膳食后，每隔30分钟对腹部进行一次成像，直到所有放射性位于结肠中，此后每隔24小时进行一次，直到所有放射性从结肠中清除。计算胃、小肠和结肠的平均通过时间。女性的胃、小肠和结肠平均通过时间明显更长。研究表明，衰老会显着加速胃和小肠的运输。在男性组中，结肠平均传输时间不受年龄影响，但中年女性的结肠传输速度明显慢于年轻女性。因此，我们得出结论，在建立胃、小肠和结肠平均通过时间的参考值时，必须考虑年龄和性别。
To investigate the effects of age and gender on gastric, small intestinal and colonic mean transit times, a study was conducted in 32 healthy volunteers: eight young women (22-30 years), eight young men (20-28 years), eight middle-aged women (43-51 years) and eight middle-aged men (38-53 years). After ingestion of a meal containing (111)Indium-labelled water and (99m)Technetium-labelled omelette imaging of the abdomen was performed at intervals of 30 min until all radioactivity was located in the colon and henceforth at intervals of 24 h until all radioactivity had cleared from the colon. Gastric, small intestinal and colonic mean transit times were calculated. The gastric, small intestinal and colonic mean transit times were significantly longer in women. Ageing was shown to accelerate the gastric and small intestinal transit significantly. In the group of men the colonic mean transit time was unaffected by age, but middle-aged women had a significantly slower colonic transit than young women. We therefore conclude that both age and gender have to be considered when reference values for gastric, small intestinal and colonic mean transit times have to be established.