Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus.
Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus.
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DOI：
10.1186/s12985-015-0421-2
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发表时间：
2015-12-22
期刊：
影响因子：
4.8
通讯作者：
Lee C
中科院分区：
文献类型：
--
作者：
Lee C
20世纪70年代初在欧洲发现的猪肠道疾病最初被描述为“流行性病毒性腹泻”，现在被称为“猪流行性腹泻（PED）”。在20世纪70年代后期，被称为PED病毒（PEDV）的冠状病毒被确定为该疾病的病原体。自那时以来，欧洲和亚洲也报告了该病，但最严重的疫情主要发生在亚洲养猪国家。最近，PED于2013年初首次在美国出现，导致与PED相关的高发病率和死亡率，显著影响了美国的生猪生产，并进一步蔓延到加拿大和墨西哥。此后不久，大规模的PED疫情在韩国、日本和台湾的猪肉行业再次出现。这些最近的爆发和全球重新出现的PED需要紧急关注和更深入地了解PEDV生物学和致病机制。本文重点介绍了PEDV的分子流行病学、诊断和致病机制以及预防和控制措施。为了开发有效的疫苗和控制策略，仍然需要更多关于病毒和疾病的信息。希望这项评论能够刺激进一步的基础和应用研究，并鼓励生产者、研究人员和猪兽医之间的合作，提供答案，提高我们对PEDV和PED的了解，以努力消除这种在经济上具有重要意义的病毒性疾病，这种疾病在世界范围内出现或重新出现。
The enteric disease of swine recognized in the early 1970s in Europe was initially described as “epidemic viral diarrhea” and is now termed “porcine epidemic diarrhea (PED)”. The coronavirus referred to as PED virus (PEDV) was determined to be the etiologic agent of this disease in the late 1970s. Since then the disease has been reported in Europe and Asia, but the most severe outbreaks have occurred predominantly in Asian swine-producing countries. Most recently, PED first emerged in early 2013 in the United States that caused high morbidity and mortality associated with PED, remarkably affecting US pig production, and spread further to Canada and Mexico. Soon thereafter, large-scale PED epidemics recurred through the pork industry in South Korea, Japan, and Taiwan. These recent outbreaks and global re-emergence of PED require urgent attention and deeper understanding of PEDV biology and pathogenic mechanisms. This paper highlights the current knowledge of molecular epidemiology, diagnosis, and pathogenesis of PEDV, as well as prevention and control measures against PEDV infection. More information about the virus and the disease is still necessary for the development of effective vaccines and control strategies. It is hoped that this review will stimulate further basic and applied studies and encourage collaboration among producers, researchers, and swine veterinarians to provide answers that improve our understanding of PEDV and PED in an effort to eliminate this economically significant viral disease, which emerged or re-emerged worldwide.