Active microelectronic neurosensor arrays for implantable brain communication interfaces.
Active microelectronic neurosensor arrays for implantable brain communication interfaces.
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DOI：
10.1109/tnsre.2009.2024310
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Nurmikko AV
中科院分区：
文献类型：
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作者：
Song YK;Borton DA;Park S;Patterson WR;Bull CW;Laiwalla F;Mislow J;Simeral JD;Donoghue JP;Nurmikko AV
我们已经建立了一个无线植入式微电子装置，用于经皮传输皮层信号。该装置旨在将微电极阵列皮质连接到外部计算机，用于神经控制应用。我们的植入式微系统通过将这些信号转换成红外光脉冲的数字流，通过皮肤传输，目前可以在非人类灵长类动物的大脑中实现16通道宽带神经记录。可植入单元采用柔性聚合物基板，我们在其上集成了超低功率放大与模拟多路复用，模数转换器，低功率数字控制器芯片和红外遥测。可扩展的16通道微系统可以采用多种供电方式，包括通过感应射频或通过光伏转换器的红外光。到目前为止，该植入物已经在非人灵长类动物中作为亚慢性单元进行了测试（约1个月），在所有可用通道上产生了强大的峰值和宽带神经数据。
We have built a wireless implantable microelectronic device for transmitting cortical signals transcutaneously. The device is aimed at interfacing a microelectrode array cortical to an external computer for neural control applications. Our implantable microsystem enables presently 16-channel broadband neural recording in a non-human primate brain by converting these signals to a digital stream of infrared light pulses for transmission through the skin. The implantable unit employs a flexible polymer substrate onto which we have integrated ultra-low power amplification with analog multiplexing, an analog-to-digital converter, a low power digital controller chip, and infrared telemetry. The scalable 16-channel microsystem can employ any of several modalities of power supply, including via radio frequency by induction, or infrared light via a photovoltaic converter. As of today, the implant has been tested as a sub-chronic unit in non-human primates (~ 1 month), yielding robust spike and broadband neural data on all available channels.