Expressive and receptive language areas determined by a non-invasive reliable method using functional magnetic resonance imaging and magnetoencephalography
Expressive and receptive language areas determined by a non-invasive reliable method using functional magnetic resonance imaging and magnetoencephalography
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DOI：
10.1227/01.neu.0000249262.03451.0e
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发表时间：
2007-02-01
期刊：
影响因子：
4.8
通讯作者：
Todo, Tomoki
中科院分区：
文献类型：
--
作者：
Kamada, Kyousuke;Sawamura, Yutaka;Todo, Tomoki
目的：众所周知，功能磁共振成像（fMRI）和脑磁图（MEG）分别对额叶和颞叶语言功能敏感。因此，我们建立了功能磁共振成像和脑磁图的结合使用，以对病理性脑部疾病中的整体语言优势进行可靠的识别。方法：我们调查了 117 名脑部病变患者，这些患者的语言优势通过 Wada 测试成功得到证实。所有患者都被要求为 fMRI 生成与声学呈现的名词相关的动词（动词生成），并为 fMRI 和 MEG 阅读三个字母的单词。 结果：fMRI 通常显示额下回和中额回的显着激活，而 MEG 上计算的偶极子通常聚集在颞上区和优势半球的梭状回。使用组合方法和 Wada 测试的有用数据对总共 87 名患者进行了进一步分析。值得注意的是，我们观察到组合方法结果与 WADA 测试结果 100% 匹配，包括两名患者的表达语言区和接受语言区分离到双侧半球。结论：结果表明，这种非侵入性和可重复的方法不仅在确定语言优势方面高度可靠，而且还可以分别定位表达语言区和接受语言区。该方法可能是世界反兴奋剂机构测试侵入性程序的有效替代方法，可用于治疗脑损伤患者。
OBJECTIVE: It is known that functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) are sensitive to the frontal and temporal language function, respectively. Therefore, we established combined use of fMRI and MEG to make reliable identification of the global language dominance in pathological brain conditions.METHODS: We investigated 117 patients with brain lesions whose language dominance was successfully confirmed by the Wada test. All patients were asked to generate verbs related to acoustically presented nouns (verb generation) for fMRI and to read three-letter words for fMRI and MEG.RESULTS: fMRI typically showed prominent activations in the inferior and middle frontal gyri, whereas calculated dipoles on MEG typically clustered in the superior temporal region and the fusiform gyrus of the dominant hemisphere. A total of 87 patients were further analyzed using useful data from both the combined method and the Wada test. Remarkably, we observed a 100% match of the combined method results with the results of the Wada test, including two patients who showed expressive and receptive language areas dissociated into bilateral hemispheres.CONCLUSION: The results demonstrate that this non-invasive and repeatable method is not only highly reliable in determining language dominance, but can also locate the expressive and receptive language areas separately. The method may be a potent alternative to invasive procedures of the Wada test and useful in treating patients with brain lesions.