PREVENTION OF LEARNED HELPLESSNESS - INVIVO CORRELATION WITH CORTICAL SEROTONIN
PREVENTION OF LEARNED HELPLESSNESS - INVIVO CORRELATION WITH CORTICAL SEROTONIN
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DOI：
10.1016/0091-3057(92)90163-a
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发表时间：
1992-10-01
影响因子：
3.6
通讯作者：
WILSON, L
中科院分区：
文献类型：
--
作者：
PETTY, F;KRAMER, G;WILSON, L
通过急性苯二氮卓类药物（BDZ）、亚慢性三环类抗抑郁药（TCA）或可逃避应激（ES）预处理可预防习得性无助（LH）。我们研究了5-羟色胺（5-HT）在这三种预防模式的LH预防中的作用，使用微透析来测量LH测试后额叶皮质（FC）中的体内5-HT释放。在不可避免的应激前接受BDZ、TCA或ES这三种预防方法中任何一种的大鼠在LH穿梭箱试验中表现出与未应激对照组相当的逃避行为。K+刺激的5-HT释放在所有三个组接受预处理也类似于幼稚的非应激对照。在不可避免的应激前接受生理盐水的大鼠在穿梭箱任务中表现出显著更多的LH行为，并且5-HT释放也显著降低。这表明LH与FC中细胞内可释放5-HT的显著减少相关，并且用于LH预防的三种不同技术，急性BDZ，亚慢性TCA和ES都类似地预防了这种5-HT消耗。
Learned helplessness (LH) is prevented by pretreatment with acute benzodiazepines (BDZs), subchronic tricyclic antidepressants (TCAs), or escapable stress (ES). We have investigated the role of serotonin (5-HT) in LH prevention by these three prevention paradigms, using microdialysis to measure in vivo 5-HT release in frontal cortex (FC) after LH testing. Rats receiving pretreatment before inescapable stress with any of the three methods of prevention - BDZs, TCAs, or ES - showed escape behavior in the shuttle-box test for LH comparable to naive unstressed controls. K+-stimulated 5-HT release in all three groups receiving pretreatment was also similar to naive unstressed controls. Rats receiving saline before inescapable stress showed significantly more LH behavior in the shuttle-box task and had significantly lower 5-HT release as well. This suggests that LH correlates with a significant decrease in intracellular releasable 5-HT in FC, and that three different techniques for LH prevention, acute BDZs, subchronic TCAs, and ES all similarly prevent this 5-HT depletion.