Possible Roles of IL-27 in the Pathogenesis of Psoriasis
Possible Roles of IL-27 in the Pathogenesis of Psoriasis
复制标题
DOI：
10.1038/jid.2009.349
复制
发表时间：
2010-04-01
影响因子：
6.5
通讯作者：
Sato, Shinichi
中科院分区：
文献类型：
--
作者：
Shibata, Sayaka;Tada, Yayoi;Sato, Shinichi
IL-27在Th1/Th17介导的各种炎症性疾病中的免疫学意义已有报道和讨论。然而，它在银屑病中的重要性尚不清楚。本研究探讨了IL-27在银屑病中的病理生理作用。银屑病患者血清IL-27水平显著高于健康对照组，且与病情严重程度及血清干扰素-γ水平呈正相关。免疫组织化学分析显示，IL-27分泌细胞在银屑病皮损的乳头状真皮中有渗透，而在特应性皮炎皮损或正常皮肤中未见。此外，单独IL-27在体外可显著诱导正常人角质形成细胞CXCL9、CXCL10和CXCL11的产生以及信号转导和转录激活子1的酪氨酸磷酸化，而抑制肿瘤坏死因子α诱导的IL-1α和CCL20的产生。这些结果表明，IL-27可能促进银屑病的发病，同时也可能减轻银屑病的炎症反应。我们的结果暗示了IL-27对银屑病的潜在治疗作用。
The immunological significance of IL-27 has been reported and discussed in various Th1/Th17-mediated inflammatory diseases. However, its importance in psoriasis is unknown. We investigated pathophysiological roles of IL-27 in psoriasis in this study. Serum IL-27 levels in psoriatic patients were significantly higher than those in healthy controls, and correlated with disease severity and serum IFN-gamma levels. An immunohistochemical analysis revealed the infiltration of IL-27-secreting cells in the papillary dermis of psoriatic skin lesions but not in skin lesions with atopic dermatitis or normal skin. Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha-induced production of IL-1 alpha and CCL20. These results indicate that IL-27 may promote the onset of psoriasis, while it may simultaneously attenuate the expanded inflammation in this disease. Our results implicate potential therapeutic effects of IL-27 for psoriasis.