ALCOHOL DETOXIFICATION AND WITHDRAWAL SEIZURES - CLINICAL SUPPORT FOR A KINDLING HYPOTHESIS
ALCOHOL DETOXIFICATION AND WITHDRAWAL SEIZURES - CLINICAL SUPPORT FOR A KINDLING HYPOTHESIS
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DOI：
10.1016/0006-3223(88)90023-6
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发表时间：
1988-03-01
影响因子：
10.6
通讯作者：
BALLENGER, JC
中科院分区：
文献类型：
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作者：
BROWN, ME;ANTON, RF;BALLENGER, JC
有人猜测，点燃模型可能适用于酒精戒断综合征和癫痫发作，这表明重复的酒精戒断可能导致后续戒断的严重程度增加。我们评估了一组男性酗酒者（n = 25）和（n = 25）酒精戒断癫痫发作的历史和临床变量。我们发现，解毒的数量似乎是一个重要的变量在倾向于戒断发作。戒断性癫痫发作组有12/25（48%）的患者有5次或以上的既往脱毒治疗，而对照组只有3/25（12%）。酒精使用史和戒断发作之间的关系没有得到数据的支持。这些发现支持了先前的酒精戒断可能“点燃”更严重的随后戒断癫痫，最终导致戒断癫痫发作的概念。
There has been speculation that a kindling model may have applicability to alcohol withdrawal syndromes and seizures, suggesting that repeated alcohol withdrawals may lead to increased severity of subsequent withdrawals. We evaluated historical and clinical variables of a group of male alcoholics with (n = 25) and without (n = 25) alcohol withdrawal seizures. We found that the number of detoxifications appeared to be an important variable in the predisposition to withdrawal seizures. The withdrawal seizure group had 12 of 25 (48%) patients with 5 or more previous detoxifications, compared to only 3 of 25 (12%) of the control group. A relationship between alcohol use history and withdrawal seizures was not supported by the data. These findings support the concept that previous alcohol withdrawals may "kindle" more serious subsequent withdrawal symptomatology, ultimately culminating in withdrawal seizures.