Modelling Cellular Processes Using Membrane Systems with Peripheral and Integral Proteins
Modelling Cellular Processes Using Membrane Systems with Peripheral and Integral Proteins
复制标题
使用具有外围和整体蛋白质的膜系统模拟细胞过程
DOI：
10.1007/11885191_8
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Sean Sedwards
中科院分区：
文献类型：
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作者：
M. Cavaliere;Sean Sedwards
膜系统被引入作为受生物细胞的结构和功能启发的计算模型。最近，膜系统也被证明是适合于模拟细胞过程。我们介绍了一个新的模型，称为膜系统与周边和整体蛋白质。该模型具有由膜封闭的隔室、漂浮物体、与膜的内部和外部表面相关联的物体以及与膜成一体的物体。漂浮物体可以在隔室内处理，并且可以与与膜相关联的物体相互作用。该模型可用于表示涉及隔室、表面和整合膜蛋白、化学物质的运输和加工的细胞过程。作为例子，我们模拟的生物钟和G-蛋白循环在酵母酿酒酵母，并提出了一个定量分析使用一个实现的模拟器。
Membrane systems were introduced as models of computation inspired by the structure and functioning of biological cells. Recently, membrane systems have also been shown to be suitable to model cellular processes. We introduce a new model called Membrane Systems with Peripheral and Integral Proteins. The model has compartments enclosed by membranes, floating objects, objects associated to the internal and external surfaces of the membranes and also objects integral to the membranes. The floating objects can be processed within the compartments and can interact with the objects associated to the membranes. The model can be used to represent cellular processes that involve compartments, surface and integral membrane proteins, transport and processing of chemical substances. As examples we model a circadian clock and the G-protein cycle in yeast saccharomyces cerevisiae and present a quantitative analysis using an implemented simulator.