Biobanking and translation of human genetics and genomics for infectious diseases.
Biobanking and translation of human genetics and genomics for infectious diseases.
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DOI：
10.1016/j.atg.2014.04.001
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发表时间：
2014-06-01
期刊：
影响因子：
--
通讯作者：
Morré SA
中科院分区：
文献类型：
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作者：
Branković I;Malogajski J;Morré SA
生物库是传染病及其宿主基因组研究的宝贵资源。本文探讨了生物库在传染病基因组学基础研究中的作用，以及生物库在传染病知识转化和临床知识吸收中的相关性和适用性。我们的研究确定了传染病基因组学和生物库之间相互作用的潜在领域，符合将基于基因组的知识整合到临床实践中的全球趋势。它还审查了专门研究传染病（包括艾滋病毒，HPV和沙眼衣原体）的各种网络和生物库，并提供了来自这些生物库的成功研究和临床吸收的例子。最后，它概述了传染病基因组学数据隐私方面的关键问题，以及充分设计和维护的电子健康记录的效用。我们认为，公众应该能够容易地获得关于学术或商业调查人员使用样本和数据的法规和程序的清晰和详细的概述，并且应该能够了解相关管理机构的确切角色。这将最终促进研究人员和诊所的吸收。由于几个网络和财团投入的努力和资源，人们越来越认识到生物库在推进传染病基因组研究、诊断及其临床管理方面的潜在用途。生物库在宿主基因组因子和传染病研究中的作用。将HIV、HPV和衣原体研究成果转化为临床成果的实例。缺乏传染病生物库的公开概述，结果是可见性低。条例和样本利用程序应更容易获得。
Biobanks are invaluable resources in genomic research of both the infectious diseases and their hosts. This article examines the role of biobanks in basic research of infectious disease genomics, as well as the relevance and applicability of biobanks in the translation of impending knowledge and the clinical uptake of knowledge of infectious diseases. Our research identifies potential fields of interaction between infectious disease genomics and biobanks, in line with global trends in the integration of genome-based knowledge into clinical practice. It also examines various networks and biobanks that specialize in infectious diseases (including HIV, HPV and Chlamydia trachomatis), and provides examples of successful research and clinical uptake stemming from these biobanks. Finally, it outlines key issues with respect to data privacy in infectious disease genomics, as well as the utility of adequately designed and maintained electronic health records. We maintain that the public should be able to easily access a clear and detailed outline of regulations and procedures for sample and data utilization by academic or commercial investigators, and also should be able to understand the precise roles of relevant governing bodies. This would ultimately facilitate uptake by researchers and clinics. As a result of the efforts and resources invested by several networks and consortia, there is an increasing awareness of the prospective uses of biobanks in advancing infectious disease genomic research, diagnostics and their clinical management. The role of biobanks in research of host genomic factors and infectious diseases. Examples of translation of HIV, HPV and Chlamydia research results into clinics. Lack of published overviews of infectious disease biobanks, result is low visibility. Regulations and sample utilization procedures should be more easily accessible.