Combinatorial signaling in the specification of unique cell fates
Combinatorial signaling in the specification of unique cell fates
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DOI：
10.1016/s0092-8674(00)00106-9
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发表时间：
2000-09-29
期刊：
影响因子：
64.5
通讯作者：
Banerjee, U
中科院分区：
文献类型：
--
作者：
Flores, GV;Duan, H;Banerjee, U
在模式形成过程中，多功能信号是如何结合起来指定独特的细胞命运的，目前还不清楚。在这里，我们证明了EGFR和Notch信号通路的核效应因子与转录因子Lozenge一起直接调节果蝇眼盘锥细胞中D-Pax2的转录。此外，D-Pax2表达的特异性可以通过这些输入的遗传操作而改变。因此，一组多能细胞接收的相对少量的时间和空间控制信号可以产生调节靶基因所需的活化转录因子的独特组合，并最终指定该组中不同的细胞命运。我们期望类似的机制可以指定脊椎动物发育系统中涉及细胞间通讯的模式形成。
How multifunctional signals combine to specify unique cell fates during pattern formation is not well understood. Here, we demonstrate that together with the transcription factor Lozenge, the nuclear effecters of the EGFR and Notch signaling pathways directly regulate D-Pax2 transcription in cone cells of the Drosophila eye disc. Moreover, the specificity of D-Pax2 expression can be altered upon genetic manipulation of these inputs. Thus, a relatively small number of temporally and spatially controlled signals received by a set of pluripotent cells can create the unique combinations of activated transcription factors required to regulate target genes and ultimately specify distinct cell fates within this group. We expect that similar mechanisms may specify pattern formation in vertebrate developmental systems that involve intercellular communication.