A low prepregnancy body mass index is a risk factor for an offspring with gastroschisis
A low prepregnancy body mass index is a risk factor for an offspring with gastroschisis
复制标题
DOI：
10.1097/00001648-199911000-00012
复制
发表时间：
1999-11-01
期刊：
影响因子：
5.4
通讯作者：
Brand, RJ
中科院分区：
文献类型：
--
作者：
Lam, PK;Torfs, CP;Brand, RJ
A mother's prepregnancy obesity has been suggested as a risk factor for having offspring with an abdominal wall defect. We evaluated this hypothesis among 104 cases of gastroschisis-a severe birth defect of the abdominal wall most prevalent in infants of young women-and 220 controls with no defect. Using Quetelet's index (QI = weight in kg/height in m(2)) as a measure of body mass, we found a higher risk of gastroschisis (odds ratio (OR) = 3.2; 95% confidence interval (CI) = 1.4-7.3) for underweight mothers (QI 28.3 kg/m(2)) as compared with mothers of normal weight. As ar was correlated to height, with the correlation varying according to mother's ethnicity and age, we adjusted for these factors in the analysis; the adjusted values approximated the unadjusted values. Evaluation of QI as a continuous variable showed that, for every unit increase in QI, the risk for gastroschisis decreased by about 11%. Sociodemographic, pregnancy, and nutrient factors did not confound the association. These results suggest that low prepregnancy body mass rather than obesity is a risk factor for gastroschisis.
