Pharmacist-led interventions to improve medication adherence in older adults: A meta-analysis.
Pharmacist-led interventions to improve medication adherence in older adults: A meta-analysis.
复制标题
药师主导的干预措施，以提高老年人的药物依从性：一项荟萃分析。
DOI：
10.1111/jgs.17373
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发表时间：
2021-11
影响因子：
6.3
通讯作者：
Ruppar TM
中科院分区：
文献类型：
--
作者：
Marcum ZA;Jiang S;Bacci JL;Ruppar TM
As pharmacists work to ensure reimbursement for chronic disease management services on the national level, evidence of their impact on important health metrics, such as medication adherence, is needed. However, summative evidence is lacking on the effectiveness of pharmacists to improve medication adherence in older adults. The objective was to assess the effectiveness of pharmacist-led interventions on medication adherence in older adults (65+ years). Using a systematic review and meta-analytic approach, a comprehensive search of publications in PubMed, Scopus, CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Google Scholar was conducted through April 2, 2020 for randomized clinical trials of pharmacist-led interventions to improve medication adherence in older adults. A standardized mean difference effect size (Cohen’s d) was calculated for medication adherence in each study. Study effect sizes were pooled using a random-effects model, with effect sizes weighted by inverse of its total variance. Medication adherence using any method of measurement. Among 40 unique randomized trials of pharmacist-led interventions with data from 8,822 unique patients (mean age, range: 65 to 85 years), the mean effect size was 0.57 (k=40; 95% Confidence Interval [CI]: 0.38–0.76). When two outlier studies were excluded from analysis, the mean effect size reduced to 0.41 (k=38; 95% CI: 0.27–0.54). A sensitivity analysis of medication adherence outcome by time point resulted in a mean effect size of 0.64 at three months (k=12; 95% CI: 0.32–0.97), 0.30 at six months (k=13; 95% CI: 0.11–0.48), 0.22 at 12 months (k=12; 95% CI: 0.08–0.37), and 0.36 for outcome time points beyond 12 months (k=5; 95% CI: 0.02–0.70). This meta-analysis found a significant improvement in medication adherence among older adults receiving pharmacist-led interventions. Implementation of pharmacist-led interventions supported by Medicare reimbursement could ensure older adults’ access to effective medication adherence support.
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影响因子：
2.3
作者：
Cooney D;Moon H;Liu Y;Miller RT;Perzynski A;Watts B;Drawz PE
通讯作者：
Drawz PE
DOI：
10.1016/j.japh.2019.07.008
发表时间：
2019-09-01
影响因子：
2.1
作者：
Clay, Patrick G.;Burns, Anne L.;Planas, Lourdes G.
通讯作者：
Planas, Lourdes G.
影响因子：
4.8
作者：
Gwadry-Sridhar, FH;Arnold, JMO;Guyatt, G
通讯作者：
Guyatt, G
影响因子：
5.9
作者：
Hanlon, JT;Weinberger, M;Feussner, JR
通讯作者：
Feussner, JR
影响因子：
3.4
作者：
Khdour, Maher R.;Kidney, Joseph C.;McElnay, James C.
通讯作者：
McElnay, James C.