Visual development of infants with severe ocular disorders.
Visual development of infants with severe ocular disorders.
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患有严重眼部疾病的婴儿的视觉发育。
DOI：
10.1016/s0161-6420(91)32138-9
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发表时间：
1991
期刊：
影响因子：
13.7
通讯作者：
Mayer,DL
中科院分区：
文献类型：
--
作者：
Fielder,AR;Fulton,AB;Mayer,DL
在 11 名婴儿早期失明、患有莱伯先天性黑蒙（5 名患者）、视神经发育不全（4 名患者）或黄斑缺损（2 名患者）的患者中，8 名在 5 至 46 个月大时出现了视觉引导行为和可测量的光栅敏锐度。所有具有可测量光栅敏锐度的儿童都表现出视觉引导的活动能力。 11 名患者中，有 10 名患者在 12 至 16 个月时，光栅敏锐度可预测其日后的视觉表现。 7 个月时达到的最佳光栅视力为 1.3 至 3.0 周期/度（20/460 至 20/200），到第 8 个月时为 0.13 周期/度（20/4700）。两名患有莱伯氏先天性黑蒙的患者和一名患有视神经发育不全的患者仍然失明。没有临床特征可以将这三名患者与视力状态改善的八名患者区分开来。后视觉通路的成熟可能是改善的基础。
Among 11 patients who presented as blind in early infancy, with Leber's congenital amaurosis (5 patients), optic nerve hypoplasia (4 patients), or macular colobomata (2 patients), 8 developed visually guided behavior and measurable grating acuity by age 5 to 46 months. All children with measurable grating acuity demonstrated visually guided mobility. Grating acuity was predictive of later visual performance in 10 of 11 patients by age 12 to 16 months. The best grating acuity attained by 7 months was 1.3 to 3.0 cycles/degree (20/460 to 20/200) and 0.13 cycles/degree (20/4700) by month 8. Two patients with Leber's congenital amaurosis and one with optic nerve hypoplasia remained blind. No clinical features existed to differentiate these three patients from the eight whose visual status improved. Posterior visual pathway maturation may underlie the improvement.