Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy
Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy
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DOI：
10.1111/j.1460-9568.2003.02993.x
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发表时间：
2003-11-01
影响因子：
3.4
通讯作者：
Blümcke, I
中科院分区：
文献类型：
--
作者：
Becker, AJ;Chen, J;Blümcke, I
癫痫活动引起海马组织和功能的深刻改变。基因组反应可能反映兴奋性刺激的直接后果以及与神经元可塑性和结构重塑相关的持续分子过程。我们使用含有8799个序列的寡核苷酸微阵列，测定了匹鲁卡品诱导癫痫大鼠的次区域基因表达谱（U34 A阵列，Affyoung，Santa Clara，CA，USA; P
Epileptic activity evokes profound alterations of hippocampal organization and function. Genomic responses may reflect immediate consequences of excitatory stimulation as well as sustained molecular processes related to neuronal plasticity and structural remodeling. Using oligonucleotide microarrays with 8799 sequences, we determined subregional gene expression profiles in rats subjected to pilocarpine-induced epilepsy (U34A arrays, Affymetrix, Santa Clara, CA, USA; P