Evaluation value of neutrophil gelatinase-associated lipocalin for the renal dysfunction of patients with chronic kidney disease: A meta-analysis.
Evaluation value of neutrophil gelatinase-associated lipocalin for the renal dysfunction of patients with chronic kidney disease: A meta-analysis.
复制标题
中性粒细胞明胶酶相关脂质运载蛋白对慢性肾脏病患者肾功能障碍的评价价值：Meta分析
DOI：
10.1002/agm2.12033
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发表时间：
2018-09-01
期刊：
影响因子：
--
通讯作者：
Zhao, Weihong
中科院分区：
文献类型：
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作者：
Guo, Lulu;Zhao, Yaya;Zhao, Weihong
目的：中性粒细胞明胶酶相关脂质运载蛋白（NGAL）在评估慢性肾病（CKD）肾功能中的作用尚未确定。我们的目的是进行荟萃分析，探讨 CKD 患者中 NGAL 与肾小球滤过率 (GFR) 之间的相关性，并进一步确定影响 NGAL 表现的因素。 方法：从 PubMed、Embase、Web of Science 和 Cochrane 图书馆检索 2017 年 11 月之前的研究。共纳入28项相关研究（涉及来自17个国家的3082名患者）。第二版诊断准确性研究质量评估表明，没有显着偏倚影响纳入研究的方法学质量。 结果：中性粒细胞明胶酶相关脂质运载蛋白与测量的肾小球滤过率 (mGFR) 呈强烈负相关。血清 NGAL (sNGAL) 和 GFR 之间相关性的汇总相关系数 (r) 以及相应的 95% 置信区间为 -0.48，同时尿液 NGAL (uNGAL) 和 GFR 之间的相关系数为 -0.34。然而，受临床环境、种族、性别、年龄和肾功能分期的限制，NGAL在亚组中的表现有所不同。结论：中性粒细胞明胶酶相关脂质运载蛋白可以作为CKD肾功能不全患者的肾功能评估标志物。与uNGAL相比，sNGAL与GFR呈显着负相关。 sNGAL 和 uNGAL 的性能受到采样源选择时应考虑的临床因素的限制。
OBJECTIVE: The role of neutrophil gelatinase-associated lipocalin (NGAL) for the evaluation of renal function in chronic kidney disease (CKD) has not yet to be determined. We aimed to perform a meta-analysis exploring the correlation between NGAL and glomerular filtration rate (GFR) in CKD patients, and to further identify factors affecting NGAL's performance.METHODS: Studies dated before November 2017 were retrieved from PubMed, Embase, Web of Science, and the Cochrane Library. A total of 28 relevant studies (involving 3082 patients from 17 countries) were included. The second version of the Quality Assessment for Studies of Diagnostic Accuracy demonstrated that no significant bias had influenced the methodological quality of the included studies.RESULTS: Neutrophil gelatinase-associated lipocalin showed a strong negative correlation with measured glomerular filtration rate (mGFR). The pooled correlation coefficient (r) with corresponding 95% confidence intervals for the correlation between serum NGAL (sNGAL) and GFR was -0.48, meanwhile that for urine NGAL (uNGAL) and GFR was -0.34. However, NGAL's performance is different in subgroups restricted by clinical settings, race, sex, age, and staging of renal function.CONCLUSION: Neutrophil gelatinase-associated lipocalin could be a renal function evaluation marker for patients with renal dysfunction in CKD. Compared with uNGAL, there was a significant negative correlation between sNGAL and GFR. The performances of sNGAL and uNGAL were restricted by clinical factors that should be considered in regards to the sampling source selection.