Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii
Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii
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Euphomilones A 和 B，ent-Rosane 二萜类化合物，具有来自大戟的 7/5/6 和 5/7/6 骨架
DOI：
10.1021/acs.orglett.6b03142
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发表时间：
2016
期刊：
影响因子：
5.2
通讯作者：
Gu Qiong
中科院分区：
文献类型：
--
作者：
Liu Shao-Nan;Huang Dane;Morris-Natschke Susan L.;Ma Hang;Liu Zhi-hong;Seeram Navindra P.;Xu Jun;Lee Kuo-Hsiung;Gu Qiong
从小米大戟（Euphorbia milii）地上部分分离得到3个高度修饰的玫瑰烷型二萜化合物，分别为Euphomilones A（1）、B（2）和Euphomianol A（3）。从物理，光谱和X-射线衍射数据，以及实验和计算的电子圆二色性（ECD）分析的结构进行了阐明。提出了1 - 3的合理生物发生途径。此外，化合物1表现出对核因子-κ B配体受体激活剂（RANKL）诱导的破骨细胞形成的抑制（IC 50 = 12.6 μM）。
Three highly modifiedent-rosane diterpenoids, euphomilones A (1) and B (2) and euphomianol A (3), were isolated from the aerial parts ofEuphorbia milii. The structures were elucidated from physical, spectroscopic, and X-ray diffraction data, as well as experimental and calculated electronic circular dichroism (ECD) analysis. Plausible biogenetic pathways to1–3are proposed. Also, compound1exhibited inhibition of receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation (IC50= 12.6 μM).