Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama Study
Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama Study
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DOI：
10.1038/ajh.2008.357
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发表时间：
2009-03-01
影响因子：
3.2
通讯作者：
Imai, Yutaka
中科院分区：
文献类型：
--
作者：
Hirose, Takuo;Hashimoto, Masahiro;Imai, Yutaka
背景近年来的研究表明，（原）肾素受体（1）是新近发现的肾素-血管紧张素系统（RAS）的成员，与动物血压调节有关。然而，没有关于人类（P）RR的信息。我们调查了日本人群中（P）RR基因多态性与血压的相关性。方法从Ohasama研究（一项日本队列研究）的参与者中招募受试者（n = 1，112）。对于关联研究，我们选择了三种多态性：-782A>G（rs 2968915），间插序列（IVS）5+ 169 C>T（rs 5918007）和+1513A>G（rs6609080）。由于（P）RR基因位于X染色体上，因此分别对男性（n = 357）和女性（n = 755）进行了分析。在男性中，IVS 5 + 169 T等位基因携带者的24小时收缩压（SBP）和舒张压（DBP）值、白天SBP和DBP值以及夜间SBP和DBP值均显著高于C等位基因携带者。多元回归分析显示IVS 5 + 169 C>T与动态血压（ABP）呈显著独立相关。IVS 5 + 169 C>T与男性偶发血压（CBP）无关。在女性中，IVS 5 + 169 C>T的三种基因型之间的血压值无显著差异。该多态性与其他临床特征无显著相关性。-782A>G与男性ABP呈弱相关。+1513A>G与男性或女性的血压值无关。CONCLUSION我们首次证明了日本男性（P）RR基因IVS 5 + 169 C>T多态性与ABP相关。这种关联表明（P）RR在血压调节中起作用。
BACKGROUNDRecent studies have revealed that (pro)renin receptor (l a newly identified member of the renin-angiotensin system (RAS), is associated with blood pressure regulation in animals. However, there is no information on (P)RR in humans. We investigated the association of (P)RR gene polymorphisms with blood pressure in a Japanese population.METHODSSubjects (n = 1,112) were recruited from participants in the Ohasama study, a Japanese cohort study. For the association study, we selected three polymorphisms: -782A>G (rs2968915), intervening sequence (IVS)5+169C>T (rs5918007), and +1513A>G (rs6609080). Because the (P)RR gene is on the X chromosome, men (n = 357) and women (n = 755) were analyzed separately.RESULTSIn men, 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP) values, daytime SBP and DBP values, and nighttime SBP and DBP values were significantly higher in IVS5+169T allele carriers than C allele carriers. Multiple regression analysis showed that IVS5+169C>T was significantly and independently related to ambulatory blood pressure (ABP). IVS5+169C>T was not associated with casual blood pressure (CBP) in men. In women, there were no significant differences in blood pressure values among the three genotypes of IVS5+169C>T. This polymorphism had no significant association with any other clinical characteristic. -782A>G was weakly associated with ABP in men. +1513A>G was not associated with blood pressure values in either men or women.CONCLUSIONSWe demonstrated for the first time that polymorphism of the (P) RR gene IVS5+169C>T is associated with ABP in Japanese men. This association suggests that (P)RR has a role in blood pressure regulation.