Functional electrical stimulation post-spinal cord injury improves locomotion and increases afferent input into the central nervous system in rats
Functional electrical stimulation post-spinal cord injury improves locomotion and increases afferent input into the central nervous system in rats
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DOI：
10.1179/2045772313y.0000000117
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发表时间：
2014-01-01
影响因子：
1.7
通讯作者：
Popovic, Milos
中科院分区：
文献类型：
--
作者：
Beaumont, Eric;Guevara, Edgar;Popovic, Milos
背景资料：功能性电刺激（FES）已被发现可有效恢复脊髓损伤（SCI）和中风后的随意功能。然而，中枢神经系统（CNS）的变化，发生在作为一个结果，这种therapeutic.Objective：探讨FES对恢复自主运动功能的中枢神经系统在SCI大鼠model.Methods的影响：SCI大鼠与慢性FES电极在后肢肌肉，并分为两组：（a）FES治疗和（B）久坐不动。在SCI后第7天，通过使用Basso，Beattie和Bresnahan（BBB）量表评估动物的运动表现。然后将它们麻醉用于终末体内实验。暴露腰髓和躯体感觉皮层，并对器械肌肉进行电刺激。结果：FES显著改善了SCI后第7天的运动恢复，如通过BBB评分所测量的（P < 0.05）：（a）FES组10 +/-2，（B）对照组3 +/-1。在1 ~ 3个运动阈值（MT）范围内，FES组脊髓和体感皮层神经血管活性明显增强（P < 0.05）。结论：FES康复治疗是改善脊髓损伤后急性期运动功能的有效方法。本研究的结果表明，FES后，CNS保留/获得对外周电刺激作出反应的能力。
Background: Functional electrical stimulation (FES) has been found to be effective in restoring voluntary functions after spinal cord injury (SCI) and stroke. However, the central nervous system (CNS) changes that occur in as a result of this therapy are largely unknown.Objective: To examine the effects of FES on the restoration of voluntary locomotor function of the CNS in a SCI rat model.Methods: SCI rats were instrumented with chronic FES electrodes in the hindlimb muscles and were divided into two groups: (a) FES therapy and (b) sedentary. At day 7 post-SCI, the animals were assessed for locomotion performance by using a Basso, Beattie and Bresnahan (BBB) scale. They were then anesthetized for a terminal in vivo experiment. The lumbar spinal cord and somatosensory cortex were exposed and the instrumented muscles were stimulated electrically. Associated neurovascular responses in the CNS were recorded with an intrinsic optical imaging system.Results: FES greatly improved locomotion recovery by day 7 post-SCI, as measured by BBB scores (P < 0.05): (a) FES 10 +/- 2 and (b) controls 3 +/- 1. Furthermore, the FES group showed a significant increase (P < 0.05) of neurovascular activation in the spinal cord and somatosensory cortex when the muscles were stimulated between 1 and 3 motor threshold (MT).Conclusion: Hind limb rehabilitation with FES is an effective strategy to improve locomotion during the acute phase post-SCI. The results of this study indicate that after FES, the CNS preserves/acquires the capacity to respond to peripheral electrical stimulation.