γ-Acetylenic GABA in Tardive Dyskinesia
γ-Acetylenic GABA in Tardive Dyskinesia
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迟发性运动障碍中的 γ-乙酰 GABA
DOI：
10.1001/archpsyc.1980.01780250062007
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发表时间：
1980
影响因子：
--
通讯作者：
T. R. Christensen
中科院分区：
文献类型：
--
作者：
D. Casey;J. Gerlach;G. Magelund;T. R. Christensen
• 脑γ-氨基丁酸(GABA) 已被认为在调节锥体外系运动功能中发挥作用。在一项盲法安慰剂对照试验中，对 10 名患有稳定迟发性运动障碍的患者评估了用 γ-乙炔 GABA (GAG)（一种抑制 GABA 转氨酶的药物）增加大脑 GABA 的效果。通过对标准化检查期间每周记录的迟发性运动障碍和帕金森病症状的随机排序录像带进行评分，评估积极治疗期间和两个安慰剂期间的药物作用。迟发性运动障碍显着减少，先前存在的帕金森病略有增加。接受较高剂量抗精神病药的患者迟发性运动障碍症状的最大程度减轻，表明 GABA 和多巴胺之间存在相互作用。催乳素值增加，但生长激素值没有变化。 GAG 治疗期间精神症状也没有变化。
• Brain γ-aminobutyric acid (GABA) has been proposed to play a role in the modulation of extrapyramidal motor function. The effects of increasing brain GABA with γ-acetylenic GABA (GAG), a drug that inhibits GABA transaminase, were evaluated in ten patients with stable tardive dyskinesia during a blind placebo-controlled trial. Drug effects during active treatment and two placebo periods were evaluated by scoring randomly sequenced videotapes of tardive dyskinesia and parkinsonian symptoms recorded weekly during a standardized examination. Tardive dyskinesia was significantly reduced, and preexisting parkinsonism increased slightly. The largest decrease in tardive dyskinesia symptoms occurred in patients receiving higher neuroleptic doses, suggesting an interaction between GABA and dopamine. Prolactin values increased but growth hormone values were unchanged. Psychiatric symptoms were also unchanged during GAG treatment.