Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression.
Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression.
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DOI：
10.1371/journal.pone.0163134
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Yamaguchi T
中科院分区：
文献类型：
--
作者：
Furusawa C;Yamaguchi T
T细胞的免疫反应通常区分自身抗原和非自身抗原，即使自身反应性T细胞的阴性选择是不完善的，并且一定比例的T细胞可以对自身抗原作出反应。在这项研究中，我们构建了一个简单的T细胞群体数学模型来分析这种自我/非自我区分是如何可能的。研究结果表明，调节性T细胞对免疫反应的控制能够对自身和非自身抗原进行稳健和准确的区分，即使T细胞对自身和非自身抗原的亲和力分布存在显著重叠。在这里，系统中调节性T细胞的数量作为控制T细胞种群动态的全局变量。本研究为免疫系统中自我和非自我歧视的定量理论的发展提供了基础，并为其实验验证提供了可能的策略。
The immune response by T cells usually discriminates self and non-self antigens, even though the negative selection of self-reactive T cells is imperfect and a certain fraction of T cells can respond to self-antigens. In this study, we construct a simple mathematical model of T cell populations to analyze how such self/non-self discrimination is possible. The results demonstrate that the control of the immune response by regulatory T cells enables a robust and accurate discrimination of self and non-self antigens, even when there is a significant overlap between the affinity distribution of T cells to self and non-self antigens. Here, the number of regulatory T cells in the system acts as a global variable controlling the T cell population dynamics. The present study provides a basis for the development of a quantitative theory for self and non-self discrimination in the immune system and a possible strategy for its experimental verification.
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影响因子：
4.3
作者：
Hong, Tian;Xing, Jianhua;Tyson, John J.
通讯作者：
Tyson, John J.
DOI：
10.1073/pnas.92.11.5042
发表时间：
1995-05-23
影响因子：
11.1
作者：
MCKEITHAN, TW
通讯作者：
MCKEITHAN, TW
影响因子：
32.4
作者：
Yamaguchi, Tomoyuki;Hirota, Keiji;Sakaguchi, Shimon
通讯作者：
Sakaguchi, Shimon
影响因子：
29.7
作者：
Josefowicz SZ;Lu LF;Rudensky AY
通讯作者：
Rudensky AY
影响因子：
2
作者：
Morton-Firth, CJ;Bray, D
通讯作者：
Bray, D