Hetero-expanded purine nucleosides. Design, synthesis and preliminary biological activity.
Hetero-expanded purine nucleosides. Design, synthesis and preliminary biological activity.
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异源扩展的嘌呤核苷。
DOI：
10.1093/nass/nrn321
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Korba,Brent
中科院分区：
文献类型：
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作者：
Seley-Radtke,KatherineL;Zhang,Zhibo;Wauchope,OrretteR;Zimmermann,SarahC;Ivanov,Alexander;Korba,Brent
我们的实验室合成了几种噻吩基扩展的嘌呤核苷类似物，用作正在进行的核酸结构和功能研究的工具。在核苷中包含噻吩环系统赋予嘌呤支架以前在其他报道的扩展嘌呤中不可用的优点。本文报道了该化合物的合成和初步生物学研究。
Several thieno-expanded purine nucleoside analogues were synthesized for use as tools in ongoing investigations into nucleic acid structure and function in our laboratories. The inclusion of the thiophene ring system in the nucleoside endows the purine scaffold with advantages not previously available in other reported expanded purines. The synthesis and preliminary biological studies are reported herein.