Alloimmunization due to red cell antibodies in Rhesus positive Omani Pregnant Women: Maternal and Perinatal outcome.
Alloimmunization due to red cell antibodies in Rhesus positive Omani Pregnant Women: Maternal and Perinatal outcome.
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DOI：
10.4103/0973-6247.162710
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发表时间：
2015-07
影响因子：
--
通讯作者：
Gowri V
中科院分区：
文献类型：
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作者：
Al-Dughaishi T;Al-Rubkhi IS;Al-Duhli M;Al-Harrasi Y;Gowri V
本研究旨在确定由于红细胞（RBC）抗原（而不是恒河猴[Rh]抗原）抗体引起的同种异体免疫的患病率，并报告母体、围产期和新生儿结局。对2011年6月至2013年6月期间在阿曼苏丹卡布斯大学医院接受随访和分娩的所有发生少量RBC抗体同种免疫的患者的病历进行回顾性审查。母亲的特点，抗体类型，抗体滴度除了围产期和新生儿的结果进行了审查。研究中有1160例Rh阳性患者。最常见的ABO血型是O，其次是A、B和AB。我们发现33 1160 Rh阳性妇女同种异体免疫与未成年人红细胞抗体，使未成年人红细胞同种异体免疫的患病率为2.7%。抗E抗体最常见（38%），其次为抗c抗体（17%）和抗kell抗体（17%）。这33例患者中有6例被确定为具有显著的抗体滴度，2例病例显示胎儿贫血的证据。只有1例需要宫内输血。最常见的新生儿并发症是黄疸，占53%，其次是呼吸窘迫综合征，占28%。2例合并新生儿贫血需产后输血。同种异体免疫抗-E，抗-C，抗-Kell是最常见的抗体之间的研究组。微量红细胞同种免疫是新生儿发病的重要原因。
This study is aimed to determine the prevalence of alloimmunization due to antibodies to red blood cell (RBC) antigens (other than rhesus [Rh] antigen) and report the maternal, perinatal, and neonatal outcomes. A retrospective review of medical records of all patients with minor RBCs antibodies alloimmunization who were followed and delivered at Sultan Qaboos University Hospital, Oman from June 2011 to June 2013. Maternal characteristics, antibody type, antibody titer in addition to perinatal and neonatal outcomes were reviewed. There were 1160 patients with Rh positive status in the study. The most common ABO blood group was O, followed by A, B, and AB. We found 33 out of 1160 Rh positive women alloimmunized with minor RBCs antibodies that gave a prevalence of minor RBCs alloimmunization of 2.7%. The most frequent antibody was anti-E 38%, followed by anti-c 17% and anti-kell 17%. 6 of these 33 patients were identified to have significant antibody titer, and two cases showed evidence of fetal anemia. Only one case required an intrauterine blood transfusion. The most common neonatal complication was jaundice in 53%, followed by respiratory distress syndrome in 28%. Two cases complicated by neonatal anemia required a postnatal blood transfusion. Alloimmunization with anti-E, anti-c, and anti-kell were the most common antibodies among the study group. Minor RBCs alloimmunization was an important cause of neonatal morbidity.