Skeletal Muscle Progenitor Cell Heterogeneity.
Skeletal Muscle Progenitor Cell Heterogeneity.
复制标题
骨骼肌祖细胞异质性。
DOI：
10.1007/978-3-030-24108-7_9
复制
发表时间：
2019
影响因子：
--
通讯作者：
Doles,JasonD
中科院分区：
文献类型：
--
作者：
Cho,DongSeong;Doles,JasonD
组织特异性干细胞有助于成体组织的维持、修复和再生。在骨骼肌中，许多不同的单核细胞类型能够产生分化的肌肉。在这些组织干细胞中，卫星细胞（SC）是研究最多的肌肉干细胞群，被广泛认为是驱动成人组织中肌肉修复和再生的主要细胞来源。在卫星细胞池中，存在许多不同的亚群，每个亚群都表现出不同的退出静止、扩展、分化和自我更新的能力。在这一章中，我们讨论了不同的干细胞类型，可以引起骨骼肌组织，然后集中在肌发生/肌肉再生过程中的卫星细胞异质性。最后，我们强调了更好地表征肌肉干细胞异质性的新机会，这将最终加深我们对肌肉发育，修复/再生，衰老和疾病中干细胞的理解。
Tissue-specific stem cells contribute to adult tissue maintenance, repair, and regeneration. In skeletal muscle, many different mononuclear cell types are capable of giving rise to differentiated muscle. Of these tissue stem-like cells, satellite cells (SCs) are the most studied muscle stem cell population and are widely considered the main cellular source driving muscle repair and regeneration in adult tissue. Within the satellite cell pool, many distinct subpopulations exist, each exhibiting differential abilities to exit quiescence, expand, differentiate, and self-renew. In this chapter, we discuss the different stem cell types that can give rise to skeletal muscle tissue and then focus on satellite cell heterogeneity during the process of myogenesis/muscle regeneration. Finally, we highlight emerging opportunities to better characterize muscle stem cell heterogeneity, which will ultimately deepen our appreciation of stem cells in muscle development, repair/regeneration, aging, and disease.