Quantification of insect genome divergence
Quantification of insect genome divergence
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DOI：
10.1016/j.tig.2006.10.004
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发表时间：
2007-01-01
影响因子：
11.4
通讯作者：
Bork, Peer
中科院分区：
文献类型：
--
作者：
Zdobnov, Evgeny M.;Bork, Peer
最近对12个昆虫基因组的测序使我们能够利用单拷贝直系同源物的同线性保守性和序列同一性来量化它们的分歧。蛋白质同一性与同线性相关性很好，并且保守性约为三倍，这一观察结果与脊椎动物之间的比较一致。观察到的同线性块长度分布遵循幂律，并且与当前公认的随机断裂模型的预期不同。我们的研究结果表明，只有有限的选择保守的基因顺序，并揭示了几百个基因，其中的接近似乎是至关重要的。
The recent sequencing of twelve insect genomes has enabled us to quantify their divergence using synteny conservation and sequence identity of single-copy orthologs. Protein identity correlates well with synteny and is about three times more conserved, an observation consistent with comparisons among vertebrates. The observed distribution of the lengths of synteny blocks follows a power law and differs from the expectations of the currently accepted random breakage model. Our results show that there is only limited selection for conservation of gene order and reveal a few hundred genes, proximity among which seems to be vital.