Reproducibility of DXA absorptiometry: a model for bone loss estimates.
Reproducibility of DXA absorptiometry: a model for bone loss estimates.
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DXA 吸收测定法的重现性：骨质流失估计模型。
DOI：
10.1002/jbmr.5650100704
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Leboff,MS
中科院分区：
文献类型：
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作者：
Fuleihan,GE;Testa,MA;Angell,JE;Porrino,N;Leboff,MS
双能 X 射线吸收测定法 (DXA) 精度更高，可以检测骨矿物质密度 (BMD) 的微小变化。必须使用适当的方差误差来评估患者 BMD 的真实临床变化。我们使用统计方差分量模型评估了我们的测量结果对真实骨质流失的响应性，该模型描述了与机器、操作员和受试者引入的误差相关的变异性。我们的技术应用于一项前瞻性研究的数据，该研究对脊柱模型以及绝经前和绝经后妇女进行了 DXA（QDR 1000W，Hologic）在同一天或相隔 4 周进行的 BMD 测量。我们的模型确定，大部分测量误差是由操作员和受试者的可变性而不是机器性能引起的。当使用适当的 CV% 来估计随时间推移骨质流失的显着性时，真实骨变化的假阳性率会显着降低。我们的研究强调需要使用适当的精度误差来评估个体受试者骨量随时间变化的临床意义。
The enhanced precision of dual‐energy X‐ray absorptiometry (DXA) allows the detection of very small changes in bone mineral density (BMD). True clinical changes in BMD in patients must be evaluated with the appropriate error of variance. We evaluated the responsiveness of our measures to true bone loss using a statistical variance components model that characterizes the variability associated with error introduced by the machine, operator, and subjects. Our techniques were applied to data from a prospective study of BMD measurements on spine phantoms and on pre‐ and postmenopausal women performed on the same day or up to 4 weeks apart with DXA (QDR 1000W, Hologic). Our model determined that most of the error in measurements was introduced by operators' and subjects' variability rather than machine performance. The false‐positive rates for true bone change are significantly reduced when the appropriate CV% is used to estimate the significance of bone loss over time. Our study underscores the need to use the appropriate precision error to evaluate the clinical significance of changes in bone mass in individual subjects over time.