Association of age with health-related quality of life in a cohort of patients with systemic lupus erythematosus: the Georgians Organized Against Lupus study.
Association of age with health-related quality of life in a cohort of patients with systemic lupus erythematosus: the Georgians Organized Against Lupus study.
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DOI：
10.1136/lupus-2016-000161
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发表时间：
2016
影响因子：
3.9
通讯作者：
Drenkard C
中科院分区：
文献类型：
--
作者：
Plantinga L;Lim SS;Bowling CB;Drenkard C
研究年龄较大是否与系统性红斑狼疮（SLE）患者的健康相关生活质量（HRQOL）较低相关，以及不同的疾病相关损害和活动是否解释了这些相关性。我们使用来自格鲁吉亚抗狼疮组织队列的684例年龄≥20岁的SLE患者的横断面数据，使用多变量线性回归估计年龄（分类为20-39岁、40-59岁和≥60岁）与HRQOL（简表-12基于常模的领域和身体成分汇总（PCS）和心理成分汇总（MCS）评分）之间的相关性。 然后，我们研究了疾病相关损害和活动对这些关联的影响。队列的平均年龄为48.2±13.1岁（范围：20-88岁），28.0%、52.9%和19.1%的受试者年龄分别为20-39岁、40-59岁和≥60岁; 79.0%为非洲裔美国人，93.7%为女性。 平均PCS评分为39.3分（20-39岁、40-59岁和≥60岁的患者分别为41.8、38.7和37.4分），而平均MCS评分为44.3分（分别为44.2、43.8和46.1分）。 一般来说，较低的身体而不是精神HRQOL评分与年龄较大。经调整后，年龄较大（分别为40-59岁和≥60岁vs 20-39岁）仍然与PCS评分较低（-2.53（-4.58至-0.67）和-3.57（-6.19至-0.96））相关（β（95%CI）），但与MCS评分无关（0.47（-1.46至2.41）和1.20（-1.52至3.92））。年龄与HRQOL领域和总分的相关性通过进一步调整疾病相关损害和/或活动没有实质性改变。在这个以非洲裔美国人为主的大型SLE患者队列中，近五分之一的参与者至少60岁。 老年与较低的身体，而不是精神，HRQOL的协会是独立的累积SLE损害和当前的SLE活动。研究结果表明，需要对SLE患者的重要老年结局进行研究，以便为老年SLE人群提供以患者为中心的临床护理。
To examine whether older age was associated with lower health-related quality of life (HRQOL) among patients with systemic lupus erythematosus (SLE) and whether differential disease-related damage and activity explained these associations. We used cross-sectional data on 684 patients with SLE aged ≥20 years from the Georgians Organized Against Lupus cohort to estimate the associations between age (categorised as 20–39, 40–59 and ≥60 years) and HRQOL (Short Form-12 norm-based domain and physical component summary (PCS) and mental component summary (MCS) scores), using multivariable linear regression. We then examined the effect of disease-related damage and activity on these associations. The mean age of the cohort was 48.2±13.1 years (range, 20–88 years), with 28.0%, 52.9% and 19.1% of participants being aged 20–39, 40–59 and ≥60 years, respectively; 79.0% were African-American and 93.7% were female. The mean PCS score was 39.3 (41.8, 38.7 and 37.4 among those aged 20–39, 40–59 and ≥60 years, respectively), while the mean MCS score was 44.3 (44.2, 43.8 and 46.1, respectively). In general, lower physical but not mental HRQOL scores were associated with older age. With adjustment, older ages (40–59 and ≥60, respectively, vs 20–39) remained associated (β (95% CI)) with lower PCS (−2.53 (−4.58 to −0.67) and −3.57 (−6.19 to −0.96)) but not MCS (0.47 (−1.46 to 2.41) and 1.20 (−1.52 to 3.92)) scores. Associations of age with HRQOL domain and summary scores were not substantially changed by further adjustment for disease-related damage and/or activity. Nearly one in five participants in this large, predominantly African-American cohort of patients with SLE was at least 60 years old. The associations of older age with lower physical, but not mental, HRQOL were independent of accumulated SLE damage and current SLE activity. The results suggest that studies of important geriatric outcomes in the setting of SLE are needed to inform patient-centred clinical care of the ageing SLE population.