Posterior Insular GABA Levels Inversely Correlate with the Intensity of Experimental Mechanical Pain in Healthy Subjects
Posterior Insular GABA Levels Inversely Correlate with the Intensity of Experimental Mechanical Pain in Healthy Subjects
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DOI：
10.1016/j.neuroscience.2017.09.043
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发表时间：
2017-10
期刊：
影响因子：
3.3
通讯作者：
Margot Thiaucourt;Polina Shabes;N. Schloss;M. Sack;U. Baumgärtner;C. Schmahl;G. Ende
中科院分区：
文献类型：
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作者：
Margot Thiaucourt;Polina Shabes;N. Schloss;M. Sack;U. Baumgärtner;C. Schmahl;G. Ende
本研究旨在探讨正常人后额叶GABA和谷氨酸水平与机械痛敏感性的关系。19名健康女性在3 T条件下进行了单体素磁共振波谱（MRS）检查。使用MEGA-PRESS光谱编辑测量右后动脉中的Metabolism。机械疼痛敏感性进行了实验性评估与针刺刺激的数字评级量表。256 mN和512 mN针刺刺激的感知强度与GABA水平呈负相关，与谷氨酸水平呈正相关。针刺疼痛评分也与谷氨酸/GABA比值呈正相关。没有观察到低于256 mN的针刺刺激的显着相关性。我们的研究结果支持这一假设，即兴奋性和抑制性神经递质水平和/或谷氨酸/GABA水平的比例在后丘脑与疼痛敏感性的个体差异。这些结果与慢性疼痛研究一致，其中观察到慢性疼痛综合征患者的岛叶皮质中谷氨酸/GABA比率升高。
This study aimed to investigate the relation of GABA and glutamate levels in the posterior insula and mechanical pain sensitivity in healthy subjects. Nineteen healthy female individuals underwent single voxel magnetic resonance spectroscopy (MRS) at 3 T. Metabolites were measured in the right posterior insula using MEGA-PRESS spectral editing. Mechanical pain sensitivity was experimentally assessed with pinprick stimuli on a numeric rating scale. Ratings of perceived intensity of 256 mN and 512 mN pinprick stimuli were negatively correlated with GABA levels and positively with glutamate levels in the posterior insula. Pinprick pain ratings were also positively correlated with the glutamate/GABA ratio. No significant correlation for pinprick stimuli of lower forces than 256 mN was observed. The results of our study support the hypothesis that excitatory and inhibitory neurotransmitter levels and/or the ratio of glutamate/GABA levels in the posterior insula are related to individual differences in pain sensitivity. These results are in line with chronic pain studies, where elevated glutamate/GABA ratios in the insular cortex of patients with chronic pain syndromes were observed.