Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging
Increased hippocampal atrophy rates in AD over 6 months using serial MR imaging
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DOI：
10.1016/j.neurobiolaging.2007.02.011
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发表时间：
2008-08-01
影响因子：
4.2
通讯作者：
Fox, N. C.
中科院分区：
文献类型：
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作者：
Barnes, J.;Scahill, R. I.;Fox, N. C.
我们对一组阿尔茨海默病患者（n = 36）和对照组受试者（n = 20）在基线、6个月和12个月的扫描中测量了海马体。我们发现，使用6个月间隔计算的平均年化萎缩率在组水平上与12个月间隔所产生的萎缩率相当。使用较短间隔时观察到更高的方差，尽管这仅在对照组中具有显著性。这在较短的扫描间隔可能具有优势的情况下具有意义，例如快速诊断以及包括在临床试验中对疾病进展的追踪。（c）2007爱思唯尔公司。保留所有权利。
We measured hippocampi on baseline-, 6- and 12-month scans in a group of AD (n = 36) and control subjects (n = 20). We found that mean annualised atrophy rates using 6-month intervals were comparable at a group level to those generated from a 12-month interval. Higher variance was seen using shorter intervals, although this was only significant in the control group. This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial. (c) 2007 Elsevier Inc. All rights reserved.