Circulating levels of tissue factor microparticle procoagulant activity are reduced with antiretroviral therapy and are associated with persistent inflammation and coagulation activation among HIV-positive patients.
Circulating levels of tissue factor microparticle procoagulant activity are reduced with antiretroviral therapy and are associated with persistent inflammation and coagulation activation among HIV-positive patients.
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DOI：
10.1097/qai.0b013e3182910121
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发表时间：
2013-07-01
期刊：
影响因子：
--
通讯作者：
Key NS
中科院分区：
文献类型：
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作者：
Baker JV;Huppler Hullsiek K;Bradford RL;Prosser R;Tracy RP;Key NS
凝血途径的激活可能会增加HIV阳性患者发生非AIDS相关疾病的风险。我们测量了163例HIV阳性受试者血浆中循环微粒（MP-TF）的组织因子依赖性促凝活性，这些受试者均未经治疗和接受病毒抑制治疗。MP-TF活性在治疗组比未治疗组低39%（p<0.001），在调整后的模型中持续存在（-36%; p=0.03）。在接受治疗的受试者中，MP-TF活性与D-二聚体（r=0.24; p=0.01）、vWF（r=0.36; p<0.001）和IL-6（r=0.20; p=0.04）水平适度相关。未来的研究应该集中在驱动残余功能TF活性的机制，以及这些改变是否对非AIDS定义的并发症有临床后果。
Activation of coagulation pathways may contribute to risk for non-AIDS related conditions among HIV positive patients. We measured tissue factor-dependent procoagulant activity on circulating microparticles (MP-TF) in the plasma of 163 HIV positive participants, both untreated and treated, with viral suppression. MP-TF activity was 39% lower among treated versus untreated participants (p<0.001), which persisted in adjusted models (−36%; p=0.03). Among treated participants, MP-TF activity correlated modestly with D-dimer (r=0.24; p=0.01), vWF (r=0.36; p<0.001), and IL-6 (r=0.20; p=0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non-AIDS defining complications.