The perilous path from publication to practice
The perilous path from publication to practice
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DOI：
10.1038/mp.2017.227
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发表时间：
2018-01-01
影响因子：
11
通讯作者：
Koutsouleris, N.
中科院分区：
文献类型：
--
作者：
Chekroud, A. M.;Koutsouleris, N.
长期以来，精准医学一直被视为临床实践的未来，至少从20世纪40年代起，保罗·米尔1和克劳德·伯纳德等人就开始讨论这一问题。2从根本上说，精确医学试图通过了解个体对特定干预措施的反应的表型特征，将重点从给定治疗的平均有效性转移到为个别患者确定最佳治疗上。然而，即使我们有证据表明某一特定特征或一组特征可能指导治疗，我们距离实现这一潜力仍有令人失望的长路要走。在这一视角下，我们希望引起读者对出版与实践之间的三种障碍的关注。
Precision medicine has long been heralded as the future of clinical practice, discussed at least since the 1940s by the likes of Paul Meehl 1 and Claude Bernard. 2 Fundamentally, precision medicine seeks to shift focus away from the average effectiveness of a given treatment to identifying the optimal treatment for an individual patient, through understanding features of the phenotype that inform the individual’s response to particular intervention. 3 However, even once we have evidence that a particular feature or group of features might guide treatment, we remain a disappointingly long way away from realizing this potential. In this Perspective, we would like to draw the readers’ attention to three kinds of obstacles between publication and practice.