Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44
Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44
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Kinanthraquinone，一种从 Streptomyces reveromyceticus SN-593-44 中分离出来的新蒽醌甲酰胺
DOI：
10.1038/s41429-017-0020-0
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Osada H
中科院分区：
文献类型：
--
作者：
Takagi H;Nogawa T;Futamura Y;Takahashi S;Osada H
从链霉菌（streptomyces reveromyceticusSN-593-44）中分离到一种新的蒽醌衍生物kinanthraquinone(1)。结合NMR和ms等波谱方法确定了其结构，Kinanthraquinone具有特征性的carboxamide基团，是一类罕见的从微生物中分离出来的蒽醌衍生物代谢产物。对HL-60和srcts- nrk细胞具有中等的细胞毒性，ic50值分别为7.9 μM和10 μM。
A new anthraquinone derivative, kinanthraquinone (1) was isolated fromStreptomyces reveromyceticusSN-593-44. Its structure was determined by the combination of spectroscopic methods including NMR and MS. Kinanthraquinone had a characteristic carboxamide group and was a rare class of metabolite as an anthraquinone derivative isolated from microbes. It showed moderate cytotoxocity against HL-60 andsrcts-NRK cell with IC50value of 7.9 and 10 μM, respectively.