Baseline affective symptomatology moderates acute subjective effects of high potency THC and CBD cannabis concentrates.
Baseline affective symptomatology moderates acute subjective effects of high potency THC and CBD cannabis concentrates.
复制标题
基线情感症状学可缓和高效 THC 和 CBD 大麻浓缩物的急性主观影响。
DOI：
10.1037/pha0000667
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发表时间：
2023
影响因子：
2.3
通讯作者：
Bidwell,LCinnamon
中科院分区：
文献类型：
--
作者：
Martin-Willett,Renée;Skrzynski,CarillonJ;Karoly,HollisC;Elmore,JoshuaS;Bidwell,LCinnamon
高效力的大麻浓缩物随处可得，并与情感障碍和大麻使用障碍有关。关于浓缩Δ、9-四氢大麻酚和大麻二酚的影响及其与长期影响的关系，人们知之甚少。我们探索了在自然使用浓缩大麻期间，基线情感症状(焦虑和抑郁)与急性(即，即时或短期)主观情绪和醉酒效应的关系。54名吸食大麻的人(女性占48%，年龄29.87岁)被随机分配使用以THC为主(84.99%THC和THCa，1%CBD)或以CBD为主(74.7%CBD，4.1%CBDa，4.5%THC和THCa)浓缩物。在自然使用其指定产品之前、之后、之后和1小时内，对个体进行评估。模型根据时间、产品状况、基线情感症状及其相互作用对每个结果进行回归。积极情绪状态与基线抑郁症状之间存在交互作用(F=9.47，p<；较高的抑郁症状水平与较高的积极情绪和主要产品的使用有关。在病情、基线抑郁症状和负性情绪持续时间之间存在交互作用(F=5.55，p<；对于所有抑郁症状级别，负面情绪随着CBD主导产品的使用而减少，但随着THC主导产品的高水平使用而增加。最后，条件与时间对中毒的影响存在交互作用(F=3.72，p=。03)；使用后，THC优势状态比CBD优势状态更醉人。这项新的探索性研究表明，基线影响缓解了随意使用THC和CBD浓缩物的急性影响，使得先前存在的情感症状调节了主观药物体验的强度。(心理信息数据库记录(C)2023年APA，保留所有权利)
Highly potent cannabis concentrates are widely available and associated with affective disturbance and cannabis use disorder. Little is known about the effects of concentrated Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and their relationship to long-term affect. We explored how baseline affective symptoms (anxiety and depression) relate to acute (ie, immediate or short-term) subjective mood and intoxication effects during naturalistic use of cannabis concentrates. Fifty-four cannabis users (48% female; M age= 29.87) were assigned to ad libitum use of either a THC-dominant (84.99% THC and THCa,< 1% CBD) or CBD-dominant (74.7% CBD, 4.1% CBDa, 4.5% THC and THCa) concentrate. Individuals were assessed at baseline and before, immediately after, and 1 hr after naturalistic use of their assigned product. Models regressed each outcome on time, product condition, baseline affective symptoms, and their interactions. An interaction emerged between condition and baseline depression symptoms on positive mood (F= 9.47, p<. 005); higher depression symptom level was associated with higher positive mood with THC-dominant product use. There was an interaction between condition, baseline depression symptoms, and time on negative mood (F= 5.55, p<. 01); negative mood decreased with CBD-dominant product use for all depression symptom levels but increased with THC-dominant product use at high levels. Finally, there was an interaction between condition and time on intoxication (F= 3.72, p=. 03); the THC-dominant condition was more intoxicated postuse than the CBD-dominant condition. This novel exploratory study suggests that baseline affect moderates the acute effects of ad libitum use of THC and CBD concentrates such that preexisting affective symptoms modulate the intensity of subjective drug experiences.(PsycInfo Database Record (c) 2023 APA, all rights reserved)