Limbic activation during cue-induced cocaine craving
Limbic activation during cue-induced cocaine craving
复制标题
DOI：
10.1176/ajp.156.1.11
复制
发表时间：
1999-01-01
影响因子：
17.7
通讯作者：
O'Brien, CP
中科院分区：
文献类型：
--
作者：
Childress, AR;Mozley, PD;O'Brien, CP
目的：由于可卡因的信号诱导动物的边缘脑激活和人类的可卡因渴望，本研究的目的是测试边缘激活是否发生在人类线索诱导的渴望。方法：使用正电子发射断层扫描，研究人员测量了14名脱毒男性可卡因使用者和6名可卡因未使用过的对照受试者在接触非药物相关和可卡因相关视频以及休息基线条件下的边缘和比较脑区域的相对局部脑血流量（CBF）。结果如下：在可卡因的视频，可卡因用户经历了渴望，并表现出一种模式，增加边缘系统（杏仁核和前扣带回）CBF和基底神经节CBF相对于他们的反应，非药物的视频。这种模式没有发生在可卡因初治的比较受试者中，并且两组在比较区域中的反应没有差异（即，背外侧前额叶皮层、小脑、丘脑和视觉皮层）。结论：提示边缘系统激活是线索诱导可卡因渴求的一个组成部分。边缘系统的激活可能同样涉及对其他药物和自然奖励的食欲渴望。
Objective: Since signals for cocaine induce limbic brain activation in animals and cocaine craving in humans, the objective of this study was to test whether limbic activation occurs during cue-induced craving in humans. Method: Using positron emission tomography, the researchers measured relative regional cerebral blood flow (CBF) in limbic and comparison brain regions of 14 detoxified male cocaine users and six cocaine-naive comparison subjects during exposure to both non-drug-related and cocaine-related videos and during resting baseline conditions. Results: During the cocaine video, the cocaine users experienced craving and showed a pattern of increases in limbic (amygdala and anterior cingulate) CBF and decreases in basal ganglia CBF relative to their responses to the nondrug video. This pattern did not occur in the cocaine-naive comparison subjects, and the two groups did not differ in their responses in the comparison regions (i.e., the dorsolateral prefrontal cortex, cerebellum, thalamus, and visual cortex). Conclusions: These findings indicate that limbic activation is one component of cue-induced cocaine craving. Limbic activation may be similarly involved in appetitive craving for other drugs and for natural rewards.